Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1365-2982.2005.00653.x
DC FieldValue
dc.titleMelatonin attenuates stress-induced defecation: Lesson from a rat model of stress-induced gut dysfunction
dc.contributor.authorSong, G.H.
dc.contributor.authorGwee, K.A.
dc.contributor.authorHo, K.Y.
dc.contributor.authorMoochhala, S.M.
dc.date.accessioned2011-09-27T05:44:23Z
dc.date.available2011-09-27T05:44:23Z
dc.date.issued2005-10
dc.identifier.citationSong, G.H., Gwee, K.A., Ho, K.Y., Moochhala, S.M. (2005-10). Melatonin attenuates stress-induced defecation: Lesson from a rat model of stress-induced gut dysfunction. Neurogastroenterology and Motility 17 (5) : 744-750. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1365-2982.2005.00653.x
dc.identifier.issn13501925
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27069
dc.description.abstractMelatonin is known to alleviate stress and modulate gut motility. We investigated the modulating effects of melatonin on stress-induced gut dysfunction. One hundred Wistar rats were randomly assigned to five equal groups, receiving intraperitoneal injections of 0, 1, 10, 100 or 1000 μg kg-1 melatonin, respectively. Fifteen minutes later, each group was divided again into four subgroups receiving no treatment, 0.25 mg luzindole (a non-selective melatonin receptor antagonist) intraperitoneally, wrap-restraint stress, and 10 mg kg-1 serotonin intraperitoneally, respectively. Two hours later, serum serotonin, corticotropin-releasing factor (CRF) and melatonin levels, and faecal output were recorded. Results showed that intraperitoneal melatonin increased faecal output, but this effect was abolished by luzindole. In wrap-restraint group, prior intraperitoneal melatonin at doses of 100 or 1000 μg kg-1 significantly inhibited stress-induced defecation. This effect was associated with corresponding reductions in serum serotonin and CRF concentrations. In serotonin-treated group, serotonin-induced defecation was also inhibited by melatonin. In conclusion, melatonin exhibited an excitatory effect on bowel output in rats placed under resting state, while attenuated defecation in those subjected to wrap-restraint stress or serotonin treatment. The inhibitory effects of melatonin on stress-induced defecation may stem from its antagonistic effect on stress-induced enhancement of serotonin and CRF secretion. © 2005 Blackwell Publishing Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1365-2982.2005.00653.x
dc.sourceScopus
dc.subjectCorticotropin-releasing factor
dc.subjectDefecation
dc.subjectMelatonin
dc.subjectSerotonin
dc.subjectStress
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1111/j.1365-2982.2005.00653.x
dc.description.sourcetitleNeurogastroenterology and Motility
dc.description.volume17
dc.description.issue5
dc.description.page744-750
dc.identifier.isiut000232708600014
dc.published.statePublished
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