Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jdiacomp.2005.10.006
DC FieldValue
dc.titleNitric oxide synthase gene polymorphisms and nephropathy in Asians with Type 2 diabetes
dc.contributor.authorLiao, L.
dc.contributor.authorLim, M.-C.
dc.contributor.authorChan, S.-W.
dc.contributor.authorLee, K.-O.
dc.contributor.authorZhao, J.-J.
dc.date.accessioned2011-09-27T05:16:10Z
dc.date.available2011-09-27T05:16:10Z
dc.date.issued2006
dc.identifier.citationLiao, L., Lim, M.-C., Chan, S.-W., Lee, K.-O., Zhao, J.-J. (2006). Nitric oxide synthase gene polymorphisms and nephropathy in Asians with Type 2 diabetes. Journal of Diabetes and its Complications 20 (6) : 371-375. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jdiacomp.2005.10.006
dc.identifier.issn10568727
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26837
dc.description.abstractObjective: Recent studies on Caucasians have reported an association between diabetic microvascular complications and polymorphisms in the inducible nitric oxide synthase (iNOS) gene. In view of the differences in the pattern of diabetic complications in Asians, we studied these iNOS polymorphisms in Asians with Type 2 diabetes who do and those who do not have nephropathy. Methods: Two hundred fifty-eight Asians who have had Type 2 diabetes for at least 10 years, with overt nephropathy or with normoalbuminuria, were genotyped for the (AAAT)n and (CCTTT)n polymorphisms in the promoter region of the iNOS gene. A subanalysis was made of the findings from the three ethnic groups (Chinese, Malays, and Indians). Results: The (AAAT)3 polymorphism, which is the most common allele in Caucasians, was completely absent in our entire cohort of 258 Asian diabetics. The (AAAT)4 polymorphism was the commonest, with a frequency of 0.984 as compared with 0.2 in Caucasians. We also found previously unreported alleles: (AAAT)5 in 6 patients and (AAAT)6 in 1 patient. There was no statistically significant association with nephropathy, in view of the highly skewed distribution of the alleles. However, the higher repeats (AAAT)5 and (AAAT)6 were found in the patients with a very rapid onset of severe nephropathy. The (CCTTT)n polymorphism also showed significant differences in allele distribution between the Asian and the Caucasian and African populations (P=.001). However, there was also no significant association with nephropathy and no significant difference in the ethnic distribution of alleles. Conclusions: We have identified significant differences in the (AAAT)n and (CCTTT)n polymorphisms in Asian diabetics. We have shown that there are significant differences in the overall allele distribution between the Asian and the Caucasian and African populations. However, our study did not demonstrate an association between iNOS gene polymorphisms and diabetic nephropathy. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jdiacomp.2005.10.006
dc.sourceScopus
dc.subjectDiabetic nephropathy
dc.subjectGene polymorphisms
dc.subjectInducible nitric oxide synthase
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.jdiacomp.2005.10.006
dc.description.sourcetitleJournal of Diabetes and its Complications
dc.description.volume20
dc.description.issue6
dc.description.page371-375
dc.identifier.isiut000241934500006
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