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Title: Changes in the Optic Disc after Acute Primary Angle Closure
Authors: Shen, S.Y.
Baskaran, M.
Fong, A.C.Y.
Lim, L.S.
Gazzard, G.
Seah, S.K.L.
Aung, T. 
Chan, Y.-H.
Husain, R.
Issue Date: 2006
Citation: Shen, S.Y., Baskaran, M., Fong, A.C.Y., Lim, L.S., Gazzard, G., Seah, S.K.L., Aung, T., Chan, Y.-H., Husain, R. (2006). Changes in the Optic Disc after Acute Primary Angle Closure. Ophthalmology 113 (6) : 924-929. ScholarBank@NUS Repository.
Abstract: Purpose: To evaluate the changes in optic disc morphology in the first 4 months after an episode of acute primary angle closure (APAC) using stereoscopic optic disc photography and computer-assisted planimetry. Design: Prospective observational case series. Participants: Forty-seven Asian subjects with unilateral APAC who were successfully treated with laser peripheral iridotomy (LPI). Main Outcome Measures: Cup-to-disc ratio (CDR) and optic cup and neuroretinal rim areas. Methods: Stereoscopic optic disc photographs were taken 2 and 16 weeks after LPI, and the images were analyzed by computer-assisted planimetry. The overall, quadrantic, and 30° sector areas of the optic disc, CDR, and neuroretinal rim area were analyzed by 2 independent masked graders, and the mean of the readings was used to calculate changes in optic disc parameters. Results: The majority of the subjects were female (66%) and Chinese (90%), and the mean age was 67.6±11.2 years (range, 40-94). In APAC eyes from week 2 to week 16, the mean CDR increased from 0.56±0.05 to 0.59±0.03 (P<0.001), and the mean neuroretinal rim area decreased from 1.74±0.31 mm2 to 1.59±0.27 mm2 (P<0.001). Quadrantic and sector analysis showed preferential loss of neuroretinal rim area at the superotemporal and inferotemporal areas. There was no significant change in optic disc parameters in the fellow eyes over the study period. Conclusions: This study demonstrated changes in optic disc morphology from week 2 to week 16 after an episode of APAC. The pattern of optic nerve damage demonstrated in our study was comparable with that seen in primary open-angle glaucoma and experimental glaucoma models. © 2006 American Academy of Ophthalmology.
Source Title: Ophthalmology
ISSN: 01616420
DOI: 10.1016/j.ophtha.2006.01.070
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