Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2008.07.021
DC FieldValue
dc.titlePreparation and evaluation of calix[4]arene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance liquid chromatography
dc.contributor.authorThamarai, Chelvi S.K.
dc.contributor.authorYong, E.L.
dc.contributor.authorGong, Y.
dc.date.accessioned2011-09-15T08:22:14Z
dc.date.available2011-09-15T08:22:14Z
dc.date.issued2008
dc.identifier.citationThamarai, Chelvi S.K., Yong, E.L., Gong, Y. (2008). Preparation and evaluation of calix[4]arene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance liquid chromatography. Journal of Chromatography A 1203 (1) : 54-58. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2008.07.021
dc.identifier.issn00219673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26022
dc.description.abstractCalix[4]arene-capped [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (C4CD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by treatment of bromoacetate-substituted [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (BACD-HPS) with calix[4]arene oxyanions in anhydrous N-methyl-2-pyrrolidone. The synthetic stationary phase is characterized by means of elemental analysis. This new type of CSP has a chiral selector with two recognition sites: calix[4]arene and β-cyclodextrin (β-CD). The chromatographic behavior of C4CD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase conditions. The results show that C4CD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of calix[4]arenes and β-CDs. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.chroma.2008.07.021
dc.sourceScopus
dc.subjectβ-Cyclodextrin
dc.subjectCalix[4]arene
dc.subjectChiral separation
dc.subjectChiral stationary phase
dc.subjectHigh-performance liquid chromatography
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.chroma.2008.07.021
dc.description.sourcetitleJournal of Chromatography A
dc.description.volume1203
dc.description.issue1
dc.description.page54-58
dc.identifier.isiut000258938500008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.