Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.virusres.2010.02.017
DC FieldValue
dc.titleDevelopment of potential antiviral strategy against coxsackievirus B4
dc.contributor.authorTan, E.L.
dc.contributor.authorWong, A.P.Y.
dc.contributor.authorPoh, C.L.
dc.date.accessioned2011-08-16T07:42:04Z
dc.date.available2011-08-16T07:42:04Z
dc.date.issued2010
dc.identifier.citationTan, E.L., Wong, A.P.Y., Poh, C.L. (2010). Development of potential antiviral strategy against coxsackievirus B4. Virus Research 150 (1-2) : 85-92. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virusres.2010.02.017
dc.identifier.issn01681702
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25624
dc.description.abstractCoxsackievirus B4 (CVB4) can cause a broad range of diseases such as aseptic meningitis, meningoencephalitis, myocarditis, hepatitis, pancreatitis, gastroenteritis, necrotizing enterocolitis, pneumonia and sudden death in the neonates. CVB4 has also been implicated as a possible etiological agent for type 1 insulin dependent diabetes mellitus (IDDM). In this study, the possibility of RNA interference (RNAi) as a potential therapeutic approach to treat CVB4 infection was explored. The results showed that the Rhabdomyosarcoma (RD) cells treated with 19-mer siRNAs displayed high specificity against CVB4 replication without displaying any sign of target effects. The siRNA targeting the 3Cpro region of CVB4 genome was also established to be the most effective in inhibition of CVB4 replication in RD cell line in a dosage dependent manner, indicating its potential to be developed as an antiviral strategy against CVB4. © 2010 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.virusres.2010.02.017
dc.sourceScopus
dc.subject19-mer siRNAs
dc.subjectCoxsackievirus B4
dc.subjectPotential antiviral strategy
dc.subjectRNA interference (RNAi)
dc.subjectType 1 insulin dependent diabetes mellitus (IDDM)
dc.subjectViral inhibition
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1016/j.virusres.2010.02.017
dc.description.sourcetitleVirus Research
dc.description.volume150
dc.description.issue1-2
dc.description.page85-92
dc.identifier.isiut000277821200011
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