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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.leukres.2009.07.003
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dc.titleGenetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group
dc.contributor.authorYeoh, A.E.-J.
dc.contributor.authorLu, Y.
dc.contributor.authorChan, J.Y.-S.
dc.contributor.authorKham, S.K.-Y.
dc.contributor.authorQuah, T.C.
dc.contributor.authorChan, Y.H.
dc.contributor.authorAriffin, H.
dc.date.accessioned2011-08-16T07:42:02Z
dc.date.available2011-08-16T07:42:02Z
dc.date.issued2010
dc.identifier.citationYeoh, A.E.-J., Lu, Y., Chan, J.Y.-S., Kham, S.K.-Y., Quah, T.C., Chan, Y.H., Ariffin, H. (2010). Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group. Leukemia Research 34 (3) : 276-283. ScholarBank@NUS Repository. https://doi.org/10.1016/j.leukres.2009.07.003
dc.identifier.issn01452126
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25622
dc.description.abstractTo study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3′-TYMS -6 bp/-6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. © 2009 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.leukres.2009.07.003
dc.sourceScopus
dc.subjectChildhood ALL
dc.subjectFolate metabolism
dc.subjectGender effect
dc.subjectGenetic epidemiology
dc.subjectMalay
dc.subjectNQO1
dc.subjectPolymorphism
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1016/j.leukres.2009.07.003
dc.description.sourcetitleLeukemia Research
dc.description.volume34
dc.description.issue3
dc.description.page276-283
dc.identifier.isiut000274529600004
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