Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.gene.2006.04.028
DC FieldValue
dc.titleCoordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis
dc.contributor.authorJackson, R.A.
dc.contributor.authorNurcombe, V.
dc.contributor.authorCool, S.M.
dc.date.accessioned2011-08-03T01:47:25Z
dc.date.available2011-08-03T01:47:25Z
dc.date.issued2006
dc.identifier.citationJackson, R.A., Nurcombe, V., Cool, S.M. (2006). Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis. Gene 379 (1-2) : 79-91. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gene.2006.04.028
dc.identifier.issn03781119
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25271
dc.description.abstractGrowth and lineage-specific differentiation constitute crucial phases in the development of stem cells. Control over these processes is exerted by particular elements of the extracellular matrix, which ultimately trigger a cascade of signals that regulate uncommitted cells, by modulating their survival and cell cycle progression, to shape developmental processes. Uncontrolled, constitutive activation of fibroblast growth factor receptors (FGFR) results in bone abnormalities, underlining the stringent control over fibroblast growth factor (FGF) activity that must be maintained for normal osteogenesis to proceed. Mounting evidence suggests that FGF signalling, together with a large number of other growth and adhesive factors, is controlled by the extracellular glycosaminoglycan sugar, heparan sulfate (HS). In this review, we focus on FGF activity during osteogenesis, their receptors, and the use of HS as a therapeutic adjuvant for bone repair. © 2006 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.gene.2006.04.028
dc.sourceScopus
dc.subjectBone
dc.subjectFGF
dc.subjectFracture repair
dc.subjectHeparin-binding growth factor
dc.subjectHS
dc.subjectOsteoblast
dc.typeArticle
dc.contributor.departmentORTHOPAEDIC SURGERY
dc.description.doi10.1016/j.gene.2006.04.028
dc.description.sourcetitleGene
dc.description.volume379
dc.description.issue1-2
dc.description.page79-91
dc.identifier.isiut000240695500009
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