Please use this identifier to cite or link to this item: https://doi.org/10.3389/fped.2024.1421051
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dc.titleDelayed colonization of Bifidobacterium spp. and low prevalence of B. infantis among infants of Asian ancestry born in Singapore: insights from the GUSTO cohort study
dc.contributor.authorXu J
dc.contributor.authorDuar RM
dc.contributor.authorQuah B
dc.contributor.authorGong M
dc.contributor.authorTin F
dc.contributor.authorChan P
dc.contributor.authorSim CK
dc.contributor.authorTan KH
dc.contributor.authorChong YS
dc.contributor.authorGluckman PD
dc.contributor.authorFrese SA
dc.contributor.authorKyle D
dc.contributor.authorKarnani N.
dc.date.accessioned2024-09-30T09:12:27Z
dc.date.available2024-09-30T09:12:27Z
dc.date.issued2024-06-24
dc.identifier.citationXu J, Duar RM, Quah B, Gong M, Tin F, Chan P, Sim CK, Tan KH, Chong YS, Gluckman PD, Frese SA, Kyle D, Karnani N. (2024-06-24). Delayed colonization of Bifidobacterium spp. and low prevalence of B. infantis among infants of Asian ancestry born in Singapore: insights from the GUSTO cohort study. Frontiers in Pediatrics 12 : 1421051. ScholarBank@NUS Repository. https://doi.org/10.3389/fped.2024.1421051
dc.identifier.issn2296-2360
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/249816
dc.description.abstractBackground: The loss of ancestral microbes, or the “disappearing microbiota hypothesis” has been proposed to play a critical role in the rise of inflammatory and immune diseases in developed nations. The effect of this loss is most consequential during early-life, as initial colonizers of the newborn gut contribute significantly to the development of the immune system. Methods: In this longitudinal study (day 3, week 3, and month 3 post-birth) of infants of Asian ancestry born in Singapore, we studied how generational immigration status and common perinatal factors affect bifidobacteria and Bifidobacterium longum subsp. infantis (B. infantis) colonization. Cohort registry identifier: NCT01174875. Results: Our findings show that first-generation migratory status, perinatal antibiotics usage, and cesarean section birth, significantly influenced the abundance and acquisition of bifidobacteria in the infant gut. Most importantly, 95.6% of the infants surveyed in this study had undetectable B. infantis, an early and beneficial colonizer of infant gut due to its ability to metabolize the wide variety of human milk oligosaccharides present in breastmilk and its ability to shape the development of a healthy immune system. A comparative analysis of B. infantis in 12 countries by their GDP per capita showed a remarkably low prevalence of this microbe in advanced economies, especially Singapore. Conclusion: This study provides new insights into infant gut microbiota colonization, showing the impact of generational immigration on early-life gut microbiota acquisition. It also warrants the need to closely monitor the declining prevalence of beneficial microbes such as B. infantis in developed nations and its potential link to increasing autoimmune and allergic diseases.
dc.publisherFrontiers
dc.subjectBifidobacterium longum subsp. Infantis
dc.subjectinfant
dc.subjectethnicity
dc.subjectimmigration
dc.subjectdelivery mode
dc.subjectantibiotics
dc.subjectgut microbiome
dc.subjectGUSTO
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentMEDICINE
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.3389/fped.2024.1421051
dc.description.sourcetitleFrontiers in Pediatrics
dc.description.volume12
dc.description.page1421051
dc.published.statePublished
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