Please use this identifier to cite or link to this item: https://doi.org/10.1073/pnas.2318641121
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dc.titleIn vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth
dc.contributor.authorZhang S
dc.contributor.authorLarsen B
dc.contributor.authorSydnor VJ
dc.contributor.authorZeng T
dc.contributor.authorAn L
dc.contributor.authorYan X
dc.contributor.authorKong R
dc.contributor.authorKong X
dc.contributor.authorGur RC
dc.contributor.authorGur RE
dc.contributor.authorMoore TM
dc.contributor.authorWolf DH
dc.contributor.authorHolmes AJ
dc.contributor.authorXie Y
dc.contributor.authorZhou JH
dc.contributor.authorFortier MV
dc.contributor.authorTan AP
dc.contributor.authorGluckman P
dc.contributor.authorChong YS
dc.contributor.authorMeaney MJ
dc.contributor.authorDeco G
dc.contributor.authorSatterthwaite TD
dc.contributor.authorYeo BTT.
dc.date.accessioned2024-09-30T09:12:20Z
dc.date.available2024-09-30T09:12:20Z
dc.date.issued2024-06-24
dc.identifier.citationZhang S, Larsen B, Sydnor VJ, Zeng T, An L, Yan X, Kong R, Kong X, Gur RC, Gur RE, Moore TM, Wolf DH, Holmes AJ, Xie Y, Zhou JH, Fortier MV, Tan AP, Gluckman P, Chong YS, Meaney MJ, Deco G, Satterthwaite TD, Yeo BTT. (2024-06-24). In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 121 (23) : e2318641121. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.2318641121
dc.identifier.issn0027-8424
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/249815
dc.description.abstractA balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I ratio remains unknown. Here, we noninvasively estimate a putative marker of whole-cortex E/I ratio by fitting a large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio marker is sensitive to the gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced E/I changes are spatially consistent with positron emission tomography measurement of benzodiazepine receptor density. We then investigate the relationship between the E/I ratio marker and neurodevelopment. We find that the E/I ratio marker declines heterogeneously across the cerebral cortex during youth, with the greatest reduction occurring in sensorimotor systems relative to association systems. Importantly, among children with the same chronological age, a lower E/I ratio marker (especially in the association cortex) is linked to better cognitive performance. This result is replicated across North American (8.2 to 23.0 y old) and Asian (7.2 to 7.9 y old) cohorts, suggesting that a more mature E/I ratio indexes improved cognition during normative development. Overall, our findings open the door to studying how disrupted E/I trajectories may lead to cognitive dysfunction in psychopathology that emerges during youth. © 2024 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
dc.publisherNational Academy of Sciences
dc.subjectcognition
dc.subjectcontrol network
dc.subjectdefault mode network
dc.subjectneurodevelopment
dc.subjectresting state functional connectivity
dc.typeArticle
dc.contributor.departmentDEAN-MED-CENTRE FOR SLEEP & COGNITION
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDIAGNOSTIC RADIOLOGY
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPAEDIATRICS
dc.contributor.departmentMEDICINE
dc.description.doi10.1073/pnas.2318641121
dc.description.sourcetitleProceedings of the National Academy of Sciences of the United States of America (PNAS)
dc.description.volume121
dc.description.issue23
dc.description.pagee2318641121
dc.published.statePublished
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