Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jss.2005.11.567
DC FieldValue
dc.titleDetection of telomerase activity in gastric lavage fluid: A novel method to detect gastric cancer
dc.contributor.authorChing-Ho, Wong S.
dc.contributor.authorYu, H.
dc.contributor.authorSo, J.B.Y.
dc.date.accessioned2011-07-27T06:38:58Z
dc.date.available2011-07-27T06:38:58Z
dc.date.issued2006
dc.identifier.citationChing-Ho, Wong S., Yu, H., So, J.B.Y. (2006). Detection of telomerase activity in gastric lavage fluid: A novel method to detect gastric cancer. Journal of Surgical Research 131 (2) : 252-255. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jss.2005.11.567
dc.identifier.issn00224804
dc.identifier.issn10958673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24959
dc.description.abstractBackground. Telomerase is a ribonucleoprotein polymerase that is essential for cell immortality. Recent studies have demonstrated that a high percentage of gastric cancer tissue expressed telomerase. This study describes the presence of telomerase activity in gastric lavage fluid in patients with gastric cancer. Methods. Gastric lavage fluid was collected during esophageogastroduodenoscopy in 70 patients: 25 with gastric cancer, 25 with peptic ulcer disease, and 20 with normal stomach. The fluid and biopsy samples were analyzed for telomerase activity by a polymerase chain reaction-based telomerase repeat amplification protocol. The findings were related to the histological results. Results. Telomerase activity was present in 24 of the 25 (96%) gastric cancer tissue and in 7 of the 25 tissue specimens from peptic ulcer or gastritis. In the gastric lavage fluid, telomerase was detected in 20 patients (80%) with gastric cancer, 7 patients (28%) with peptic ulcer, and none in normal subjects (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of gastric fluid telomerase expression in gastric cancer patients was 80%, 84%, 74%, and 88%, respectively. Conclusions. The presence of telomerase activity is present in gastric lavage fluid of patients with gastric cancer as compared to those without, may represent a novel method for diagnosis of gastric cancer. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jss.2005.11.567
dc.sourceScopus
dc.subjectGastric cancer
dc.subjectGastric lavage fluid
dc.subjectHelicobacter pylori
dc.subjectTelomerase activity
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.jss.2005.11.567
dc.description.sourcetitleJournal of Surgical Research
dc.description.volume131
dc.description.issue2
dc.description.page252-255
dc.identifier.isiut000236257200013
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Jul 19, 2019

WEB OF SCIENCETM
Citations

10
checked on Jul 19, 2019

Page view(s)

119
checked on Jun 22, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.