PHOTO-INDUCED HYDROGEN ATOM TRANSFER AND HALOGEN ATOM TRANSFER FOR C-H AND C-X BOND ACTIVATION

Abstract

In recent years, photocatalysis has experienced a remarkable resurgence, introducing a range of new activation modes and consequently enabling the development of numerous bond-forming protocols and synthetic methodologies. My first project is focused on developing a divergent photo-induced radical addition from the aldehyde to nitrobenzene via HAT process. This study represents a rare example of photo-reductive coupling of nitrobenzene. The reductive catalytic process relies on the critical and versatile functions of TBADT, which not only activates the aldehydic C-H bond to generate acyl radicals but also employs transferred hydrogen to facilitate the overall reductive coupling. My second project is the development of a method of visible-light-induced halogen atom transfer (XAT) reactions. I delve into the potential utility of eosin Y as a direct photo-HAT catalyst, endowed with the capacity to engender silyl radicals and expedite the initiation of C-X bond activation. Additionally, our investigations reveal that the manipulation of reaction temperature could wield substantial influence over the XAT rate which give me a chance to realize the activation of strong C-Cl and C-F bonds.