Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.imbio.2006.02.004
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dc.titleIron-withholding strategy in innate immunity
dc.contributor.authorOng, S.T.
dc.contributor.authorDing, J.L.
dc.contributor.authorShan, Ho J.Z.
dc.contributor.authorHo, B.
dc.date.accessioned2011-07-26T07:06:01Z
dc.date.available2011-07-26T07:06:01Z
dc.date.issued2006
dc.identifier.citationOng, S.T., Ding, J.L., Shan, Ho J.Z., Ho, B. (2006). Iron-withholding strategy in innate immunity. Immunobiology 211 (4) : 295-314. ScholarBank@NUS Repository. https://doi.org/10.1016/j.imbio.2006.02.004
dc.identifier.issn01712985
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24889
dc.description.abstractThe knowledge of how organisms fight infections has largely been built upon the ability of host innate immune molecules to recognize microbial determinants. Although of overwhelming importance, pathogen recognition is but only one of the facets of innate immunity. A primitive yet effective antimicrobial mechanism which operates by depriving microbial organisms of their nutrients has been brought into the forefront of innate immunity once again. Such a tactic is commonly referred to as the iron-withholding strategy of innate immunity. In this review, we introduce various vertebrate iron-binding proteins and their invertebrate homologues, so as to impress upon readers an obscured arm of innate immune defense. An excellent comprehension of the mechanics of innate immunity paves the way for the possibility that novel antimicrobial therapeutics may emerge one day to overcome the prevalent antibiotic resistance in bacteria. © 2006 Elsevier GmbH. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.imbio.2006.02.004
dc.sourceScopus
dc.subjectFerritin
dc.subjectHepcidin
dc.subjectInnate immunity
dc.subjectIron sequestration
dc.subjectLipocalin
dc.subjectNramp
dc.subjectTransferrin
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1016/j.imbio.2006.02.004
dc.description.sourcetitleImmunobiology
dc.description.volume211
dc.description.issue4
dc.description.page295-314
dc.identifier.isiut000238483400007
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