Please use this identifier to cite or link to this item: https://doi.org/10.4103/tjo.TJO-D-23-00018
Title: Eyes as the windows into cardiovascular disease in the era of big data
Authors: Chan, Y 
Cheng, CY 
Sabanayagam, C 
Keywords: Biomarker discovery
cardiovascular disease
cardiovascular risk stratification
deep learning
oculomics
Issue Date: 1-Apr-2023
Publisher: Medknow
Citation: Chan, Y, Cheng, CY, Sabanayagam, C (2023-04-01). Eyes as the windows into cardiovascular disease in the era of big data. Taiwan Journal of Ophthalmology 13 (2) : 151-167. ScholarBank@NUS Repository. https://doi.org/10.4103/tjo.TJO-D-23-00018
Abstract: Cardiovascular disease (CVD) is a major cause of mortality and morbidity worldwide and imposes significant socioeconomic burdens, especially with late diagnoses. There is growing evidence of strong correlations between ocular images, which are information-dense, and CVD progression. The accelerating development of deep learning algorithms (DLAs) is a promising avenue for research into CVD biomarker discovery, early CVD diagnosis, and CVD prognostication. We review a selection of 17 recent DLAs on the less-explored realm of DL as applied to ocular images to produce CVD outcomes, potential challenges in their clinical deployment, and the path forward. The evidence for CVD manifestations in ocular images is well documented. Most of the reviewed DLAs analyze retinal fundus photographs to predict CV risk factors, in particular hypertension. DLAs can predict age, sex, smoking status, alcohol status, body mass index, mortality, myocardial infarction, stroke, chronic kidney disease, and hematological disease with significant accuracy. While the cardio-oculomics intersection is now burgeoning, very much remain to be explored. The increasing availability of big data, computational power, technological literacy, and acceptance all prime this subfield for rapid growth. We pinpoint the specific areas of improvement toward ubiquitous clinical deployment: increased generalizability, external validation, and universal benchmarking. DLAs capable of predicting CVD outcomes from ocular inputs are of great interest and promise to individualized precision medicine and efficiency in the provision of health care with yet undetermined real-world efficacy with impactful initial results.
Source Title: Taiwan Journal of Ophthalmology
URI: https://scholarbank.nus.edu.sg/handle/10635/248885
ISSN: 2211-5056
2211-5072
DOI: 10.4103/tjo.TJO-D-23-00018
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Eyes as the windows into cardiovascular disease in the era of big data.pdfPublished version2.27 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.