Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s00395-023-01019-9
DC Field | Value | |
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dc.title | Targeting mitochondrial shape: at the heart of cardioprotection | |
dc.contributor.author | Hernandez-Resendiz, Sauri | |
dc.contributor.author | Prakash, Aishwarya | |
dc.contributor.author | Loo, Sze Jie | |
dc.contributor.author | Semenzato, Martina | |
dc.contributor.author | Chinda, Kroekkiat | |
dc.contributor.author | Crespo-Avilan, Gustavo E | |
dc.contributor.author | Dam, Linh Chi | |
dc.contributor.author | Lu, Shengjie | |
dc.contributor.author | Scorrano, Luca | |
dc.contributor.author | Hausenloy, Derek J | |
dc.date.accessioned | 2024-06-11T08:35:11Z | |
dc.date.available | 2024-06-11T08:35:11Z | |
dc.date.issued | 2023-11-13 | |
dc.identifier.citation | Hernandez-Resendiz, Sauri, Prakash, Aishwarya, Loo, Sze Jie, Semenzato, Martina, Chinda, Kroekkiat, Crespo-Avilan, Gustavo E, Dam, Linh Chi, Lu, Shengjie, Scorrano, Luca, Hausenloy, Derek J (2023-11-13). Targeting mitochondrial shape: at the heart of cardioprotection. BASIC RESEARCH IN CARDIOLOGY 118 (1). ScholarBank@NUS Repository. https://doi.org/10.1007/s00395-023-01019-9 | |
dc.identifier.issn | 0300-8428 | |
dc.identifier.issn | 1435-1803 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/248788 | |
dc.description.abstract | There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI. | |
dc.language.iso | en | |
dc.publisher | SPRINGER HEIDELBERG | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cardiac & Cardiovascular Systems | |
dc.subject | Cardiovascular System & Cardiology | |
dc.subject | Cardiovascular diseases | |
dc.subject | Acute myocardial ischemia-reperfusion injury | |
dc.subject | Acute myocardial infarction | |
dc.subject | Heart failure | |
dc.subject | Mitochondrial morphology | |
dc.subject | Cardioprotection | |
dc.subject | ISCHEMIA-REPERFUSION INJURY | |
dc.subject | DYNAMIN-RELATED PROTEIN-1 | |
dc.subject | CYTOSOLIC CALCIUM OVERLOAD | |
dc.subject | MYOCARDIAL-ISCHEMIA | |
dc.subject | CALORIC RESTRICTION | |
dc.subject | PERMEABILITY TRANSITION | |
dc.subject | ISCHAEMIA/REPERFUSION INJURY | |
dc.subject | ISCHEMIA/REPERFUSION INJURY | |
dc.subject | STRUCTURAL DIFFERENCES | |
dc.subject | ENDOPLASMIC-RETICULUM | |
dc.type | Article | |
dc.date.updated | 2024-06-11T02:17:22Z | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.description.doi | 10.1007/s00395-023-01019-9 | |
dc.description.sourcetitle | BASIC RESEARCH IN CARDIOLOGY | |
dc.description.volume | 118 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Targeting mitochondrial shape at the heart of cardioprotection.pdf | 1.52 MB | Adobe PDF | OPEN | None | View/Download |
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