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https://scholarbank.nus.edu.sg/handle/10635/248177
Title: | THREE-DIMENSIONAL LIQUID METAL-BASED CONFORMAL NEURO-INTERFACES FOR HUMAN HIPPOCAMPAL ORGANOIDS | Authors: | WU YAN | ORCID iD: | ![]() |
Keywords: | Neural organoid, Hippocampus, 3D soft electronics, Neural interface, Mesh electrodes, Liquid metal-polymer conductor | Issue Date: | 14-Jul-2023 | Citation: | WU YAN (2023-07-14). THREE-DIMENSIONAL LIQUID METAL-BASED CONFORMAL NEURO-INTERFACES FOR HUMAN HIPPOCAMPAL ORGANOIDS. ScholarBank@NUS Repository. | Abstract: | Human hippocampal organoids derived from stem cells have emerged as promising models for investigating neurodegenerative disorders. However, obtaining the electrical information of these free-floating organoids remains a challenge using commercial multi-electrode arrays (MEAs). The 3D MEAs developed recently acquired only a few neural signals due to limited channel numbers. Here, I present that under Wnt3a and SHH activator induction, the organoid produced hippocampal progenitors and dentate gyrus granule neurons. The transcriptomic signatures of the organoid reveal a high similarity to the developing human hippocampus. I report a platform coupling a liquid metal-polymer conductor (MPC)-based mesh neuro-interface with hippocampal organoids. The mesh MPC (mMPC) integrated 128 electrodes distributed on a small surface area. Softness of the mMPC enable its conformal attachment to the organoid. I successfully detected neural signals from this complex. Compared with traditional planar devices, the non-invasive coupling offers an adaptor for recording neural signals from 3D models. | URI: | https://scholarbank.nus.edu.sg/handle/10635/248177 |
Appears in Collections: | Ph.D Theses (Open) |
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