Please use this identifier to cite or link to this item:
https://doi.org/10.1126/science.abe6821
DC Field | Value | |
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dc.title | Maturation of the matrix and viral membrane of HIV-1 | |
dc.contributor.author | Qu, Kun | |
dc.contributor.author | Ke, Zunlong | |
dc.contributor.author | Zila, Vojtech | |
dc.contributor.author | Anders-Oesswein, Maria | |
dc.contributor.author | Glass, Barbel | |
dc.contributor.author | Muecksch, Frauke | |
dc.contributor.author | Mueller, Rainer | |
dc.contributor.author | Schultz, Carsten | |
dc.contributor.author | Mueller, Barbara | |
dc.contributor.author | Kraeusslich, Hans-Georg | |
dc.contributor.author | Briggs, John AG | |
dc.date.accessioned | 2024-04-02T02:27:00Z | |
dc.date.available | 2024-04-02T02:27:00Z | |
dc.date.issued | 2021-08-06 | |
dc.identifier.citation | Qu, Kun, Ke, Zunlong, Zila, Vojtech, Anders-Oesswein, Maria, Glass, Barbel, Muecksch, Frauke, Mueller, Rainer, Schultz, Carsten, Mueller, Barbara, Kraeusslich, Hans-Georg, Briggs, John AG (2021-08-06). Maturation of the matrix and viral membrane of HIV-1. SCIENCE 373 (6555) : 700-704. ScholarBank@NUS Repository. https://doi.org/10.1126/science.abe6821 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.issn | 1095-9203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/247693 | |
dc.description.abstract | Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component domains, causing structural maturation to repurpose the virion for cell entry. We determined the structure and arrangement of MA within immature and mature HIV-1 through cryo-electron tomography. We found that MA rearranges between two different hexameric lattices upon maturation. In mature HIV-1, a lipid extends out of the membrane to bind with a pocket in MA. Our data suggest that proteolytic maturation of HIV-1 not only assembles the viral capsid surrounding the genome but also repurposes the membrane-bound MA lattice for an entry or postentry function and results in the partial removal of up to 2500 lipids from the viral membrane. | |
dc.language.iso | en | |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | IMMUNODEFICIENCY-VIRUS TYPE-1 | |
dc.subject | ENVELOPE INCORPORATION | |
dc.subject | PLASMA-MEMBRANE | |
dc.subject | BINDING | |
dc.subject | PROTEIN | |
dc.subject | RETROVIRUS | |
dc.subject | PHOSPHATIDYLINOSITOL-(4,5)-BISPHOSPHATE | |
dc.subject | VISUALIZATION | |
dc.subject | RESOLUTION | |
dc.subject | FUSION | |
dc.type | Article | |
dc.date.updated | 2024-04-01T09:20:21Z | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1126/science.abe6821 | |
dc.description.sourcetitle | SCIENCE | |
dc.description.volume | 373 | |
dc.description.issue | 6555 | |
dc.description.page | 700-704 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Maturation of the matrix and viral membrane of HIV-1.pdf | 1.9 MB | Adobe PDF | OPEN | Post-print | View/Download |
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