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https://doi.org/10.1016/j.bbrc.2009.08.108
DC Field | Value | |
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dc.title | Specific interaction of capsid protein and importin-α/β influences West Nile virus production | |
dc.contributor.author | Bhuvanakantham, R. | |
dc.contributor.author | Chong, M.-K. | |
dc.contributor.author | Ng, M.-L. | |
dc.date.accessioned | 2011-07-26T06:53:48Z | |
dc.date.available | 2011-07-26T06:53:48Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Bhuvanakantham, R., Chong, M.-K., Ng, M.-L. (2009). Specific interaction of capsid protein and importin-α/β influences West Nile virus production. Biochemical and Biophysical Research Communications 389 (1) : 63-69. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2009.08.108 | |
dc.identifier.issn | 0006291X | |
dc.identifier.issn | 10902104 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/24732 | |
dc.description.abstract | West Nile virus (WNV) capsid (C) protein has been shown to enter the nucleus of infected cells. However, the mechanism by which C protein enters the nucleus is unknown. In this study, we have unveiled for the first time that nuclear transport of WNV and Dengue virus C protein is mediated by their direct association with importin-α. This interplay is mediated by the consensus sequences of bipartite nuclear localization signal located between amino acid residues 85-101 together with amino acid residues 42 and 43 of C protein. Elucidation of biological significance of importin-α/C protein interaction demonstrated that the binding efficiency of this association influenced the nuclear entry of C protein and virus production. Collectively, this study illustrated the molecular mechanism by which the C protein of arthropod-borne flavivirus enters the nucleus and showed the importance of importin-α/C protein interaction in the context of flavivirus life-cycle. © 2009 Elsevier Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2009.08.108 | |
dc.source | Scopus | |
dc.subject | Binding strength | |
dc.subject | Capsid | |
dc.subject | Importin | |
dc.subject | Virus production | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY | |
dc.description.doi | 10.1016/j.bbrc.2009.08.108 | |
dc.description.sourcetitle | Biochemical and Biophysical Research Communications | |
dc.description.volume | 389 | |
dc.description.issue | 1 | |
dc.description.page | 63-69 | |
dc.identifier.isiut | 000274534900012 | |
Appears in Collections: | Staff Publications |
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