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https://scholarbank.nus.edu.sg/handle/10635/247170
DC Field | Value | |
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dc.title | Customizing the degradation and load-bearing profile of 3D polycaprolactone-tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions | |
dc.contributor.author | Yeo, A | |
dc.contributor.author | Sju, E | |
dc.contributor.author | Rai, B | |
dc.contributor.author | Teoh, SH | |
dc.date.accessioned | 2024-02-20T00:37:00Z | |
dc.date.available | 2024-02-20T00:37:00Z | |
dc.date.issued | 2008-11-01 | |
dc.identifier.citation | Yeo, A, Sju, E, Rai, B, Teoh, SH (2008-11-01). Customizing the degradation and load-bearing profile of 3D polycaprolactone-tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions. Journal of Biomedical Materials Research - Part B Applied Biomaterials 87 (2) : 562-569. ScholarBank@NUS Repository. | |
dc.identifier.issn | 1552-4973 | |
dc.identifier.issn | 1552-4981 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/247170 | |
dc.description.abstract | The degradation of polycaprolactone-20% tricalcium phosphate (PCL-TCP) scaffolds was customized for dentoalveolar augmentation applications, where 5-6 months period is optimal. The scaffolds were treated with either 3M sodium hydroxide (NaOH) or 0.1% lipase solution for a total of 108 h. A greater degree of degradation and reduction in the physical properties of the scaffolds was observed in the lipase treated when compared with NaOH-treated scaffolds. After 108 h, increases in weight loss and average porosity of the scaffolds in the lipase-treated group measured 90.6% and 22.9%, respectively, when compared with 52.8% and 11.8% in the NaOH-treated group. The mechanical testing results revealed a similar trend, with a complete loss of compressive strength and modulus measured as early as 60 h in the lipase-treated group. The honeycomblike architecture was well preserved throughout the experiment only for the NaOH-treated scaffolds in addition to a favorable surface roughness ideal for bone-regeneration applications. In conclusion, pretreatment with NaOH demonstrates a simple approach for tailoring the physical properties and degradation rate of PCL-TCP scaffolds for the potential use as biomaterials targeted for dentoalveolar bone-regeneration procedures. © 2008 Wiley Periodicals, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jbm.b.31145 | |
dc.publisher | Wiley | |
dc.source | Elements | |
dc.subject | Calcium Phosphates | |
dc.subject | Hydrolysis | |
dc.subject | Lipase | |
dc.subject | Microscopy, Electron, Scanning | |
dc.subject | Models, Molecular | |
dc.subject | Molecular Weight | |
dc.subject | Polyesters | |
dc.subject | Stress, Mechanical | |
dc.subject | Tomography, X-Ray Computed | |
dc.type | Article | |
dc.date.updated | 2024-02-19T09:11:28Z | |
dc.contributor.department | DEAN'S OFFICE (DENTISTRY) | |
dc.contributor.department | MECHANICAL ENGINEERING | |
dc.description.sourcetitle | Journal of Biomedical Materials Research - Part B Applied Biomaterials | |
dc.description.volume | 87 | |
dc.description.issue | 2 | |
dc.description.page | 562-569 | |
dc.description.coden | JBMRG | |
dc.identifier.isiut | 000260355000032 | |
dc.published.state | Published | |
dc.description.redeposit | completed | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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J Biomed Mater Res - 2008 - Yeo - Customizing the degradation and load‐bearing profile of 3D polycaprolactone‐tricalcium.pdf | Published version | 348.43 kB | Adobe PDF | CLOSED | Published | |
J Biomed Mater Res - 2008 - Yeo - Customizing the degradation and load‐bearing profile of 3D polycaprolactone‐tricalcium.pdf | Accepted version | 348.43 kB | Adobe PDF | CLOSED | Published |
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