Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/247167
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dc.titleSurface modification of PCL-TCP scaffolds in rabbit calvaria defects: Evaluation of scaffold degradation profile, biomechanical properties and bone healing patterns
dc.contributor.authorYeo, A
dc.contributor.authorWong, WJ
dc.contributor.authorTeoh, SH
dc.date.accessioned2024-02-20T00:05:24Z
dc.date.available2024-02-20T00:05:24Z
dc.date.issued2010-06-15
dc.identifier.citationYeo, A, Wong, WJ, Teoh, SH (2010-06-15). Surface modification of PCL-TCP scaffolds in rabbit calvaria defects: Evaluation of scaffold degradation profile, biomechanical properties and bone healing patterns. Journal of Biomedical Materials Research - Part A 93 (4) : 1358-1367. ScholarBank@NUS Repository.
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/247167
dc.description.abstractTraditionally, polycaprolactone (PCL) based scaffolds tend to degrade at a slow rate. Pretreatment of polycaprolactone-20% tricalcium phosphate (PCL-TCP) scaffolds under alkaline conditions can be utilized to increase the degradation rate and improve mechanical properties. Three groups of PCL-TCP scaffolds with varying pretreatment exposures with sodium hydroxide (NaOH) were studied in a rabbit calvaria defect model and analyzed at 2, 4, 8, 12, and 24 weeks. (Group A: Untreated, Group B: 3 M NaOH/48 h and Group C: 3 M NaOH/96 h). Micro-CT analysis demonstrated that scaffolds with increased surface roughness (Groups B and C) showed a greater impact on the overall volume loss during the early healing period between 2 and 8 weeks as compared to the untreated group. In addition, greater bone formation was detected in NaOH treated scaffolds as compared to the untreated group throughout the experiment. Scaffolds with increased surface roughness generally reported higher push out test and compressive strength values from 4 to 8 weeks of early healing. Interestingly, the mechanical properties displayed a decline in values from 12 weeks onwards in the modified groups suggesting a favorable breakdown or weakening of PCL-TCP scaffolds tailored for replacement by new bone formation. © 2009 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jbm.a.32633
dc.publisherWiley
dc.sourceElements
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBiomechanical Phenomena
dc.subjectBone and Bones
dc.subjectCalcium Phosphates
dc.subjectMale
dc.subjectOsteogenesis
dc.subjectPolyesters
dc.subjectRabbits
dc.subjectSkull
dc.subjectSodium Hydroxide
dc.subjectStress, Mechanical
dc.subjectSurface Properties
dc.subjectTime Factors
dc.subjectX-Ray Microtomography
dc.typeArticle
dc.date.updated2024-02-19T08:56:07Z
dc.contributor.departmentDEAN'S OFFICE (DENTISTRY)
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.sourcetitleJournal of Biomedical Materials Research - Part A
dc.description.volume93
dc.description.issue4
dc.description.page1358-1367
dc.description.codenJBMRC
dc.identifier.isiut000277523600015
dc.published.statePublished
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