Please use this identifier to cite or link to this item: https://doi.org/10.1097/PSY.0000000000000370
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dc.titleSuggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI-Based Brain Activity
dc.contributor.authorDerbyshire, Stuart WG
dc.contributor.authorWhalley, Matthew G
dc.contributor.authorSeah, Stanley TH
dc.contributor.authorOakley, David A
dc.date.accessioned2024-02-15T01:21:13Z
dc.date.available2024-02-15T01:21:13Z
dc.date.issued2017-02-01
dc.identifier.citationDerbyshire, Stuart WG, Whalley, Matthew G, Seah, Stanley TH, Oakley, David A (2017-02-01). Suggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI-Based Brain Activity. PSYCHOSOMATIC MEDICINE 79 (2) : 189-200. ScholarBank@NUS Repository. https://doi.org/10.1097/PSY.0000000000000370
dc.identifier.issn0033-3174
dc.identifier.issn1534-7796
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/247135
dc.description.abstractObjective Hypnotic suggestion is an empirically validated form of pain control; however, the underlying mechanism remains unclear. Methods Thirteen fibromyalgia patients received suggestions to alter their clinical pain, and 15 healthy controls received suggestions to alter experimental heat pain. Suggestions were delivered before and after hypnotic induction with blood oxygen level-dependent (BOLD) activity measured concurrently. Results Across groups, suggestion produced substantial changes in pain report (main effect of suggestion, F2, 312 = 585.8; p <.0001), with marginally larger changes after induction (main effect of induction, F1, 312 = 3.6; p =.060). In patients, BOLD response increased with pain report in regions previously associated with pain, including thalamus and anterior cingulate cortex. In controls, BOLD response decreased with pain report. All changes were greater after induction. Region-of-interest analysis revealed largely linear patient responses with increasing pain report. Control responses, however, were higher after suggestion to increase or decrease pain from baseline. Conclusions Based on behavioral report alone, the mechanism of suggestion could be interpreted as largely similar regardless of the induction or type of pain experience. The functional magnetic resonance imaging data, however, demonstrated larger changes in brain activity after induction and a radically different pattern of brain activity for clinical pain compared with experimental pain. These findings imply that induction has an important effect on underlying neural activity mediating the effects of suggestion, and the mechanism of suggestion in patients altering clinical pain differs from that in controls altering experimental pain. Patient responses imply that suggestions altered pain experience via corresponding changes in pain-related brain regions, whereas control responses imply suggestion engaged cognitive control.
dc.language.isoen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.sourceElements
dc.subjectScience & Technology
dc.subjectSocial Sciences
dc.subjectLife Sciences & Biomedicine
dc.subjectPsychiatry
dc.subjectPsychology
dc.subjectPsychology, Multidisciplinary
dc.subjectchronic pain
dc.subjectfunctional magnetic resonance imaging
dc.subjectexperimental pain
dc.subjecthypnosis
dc.subjectalternative therapy
dc.subjectbrain
dc.subjectIRRITABLE-BOWEL-SYNDROME
dc.subjectRESTING-STATE FMRI
dc.subjectDEFAULT MODE
dc.subjectCOGNITIVE NEUROSCIENCE
dc.subjectALTERED STATE
dc.subjectHYPNOSIS
dc.subjectMETAANALYSIS
dc.subjectPERCEPTION
dc.subjectMODULATION
dc.subjectACTIVATION
dc.typeArticle
dc.date.updated2024-02-15T01:11:38Z
dc.contributor.departmentPSYCHOLOGY
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1097/PSY.0000000000000370
dc.description.sourcetitlePSYCHOSOMATIC MEDICINE
dc.description.volume79
dc.description.issue2
dc.description.page189-200
dc.published.stateen
dc.published.stateAccepted
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