Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.imbio.2006.11.008
DC FieldValue
dc.titleThe regulatory roles of C1q
dc.contributor.authorLu, J.
dc.contributor.authorWu, X.
dc.contributor.authorTeh, B.K.
dc.date.accessioned2011-07-26T06:52:44Z
dc.date.available2011-07-26T06:52:44Z
dc.date.issued2007
dc.identifier.citationLu, J., Wu, X., Teh, B.K. (2007). The regulatory roles of C1q. Immunobiology 212 (4-5) : 245-252. ScholarBank@NUS Repository. https://doi.org/10.1016/j.imbio.2006.11.008
dc.identifier.issn01712985
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24663
dc.description.abstractC1q binds to immune complexes to elicit complement-dependent microbial killing and enhance phagocytosis. Besides this classical role, C1q also opsonizes apoptotic cells for clearance by phagocytes. C1q deficiency increases susceptibility to microbial infections and is also associated with elevated autoimmunity as characterized by increased apoptotic bodies in tissues. Most complement proteins are of liver origin, but C1q is predominantly synthesized by peripheral tissue macrophages and dendritic cells. Besides being found in the blood, C1q has also been found deposited in extracellular tissues around these cells. In vitro, immobilized C1q inhibits monocyte, macrophage and T-cell production of inflammatory cytokines. It also regulates T-cell activation. Therefore, mounting evidence suggest a major regulatory role for C1q in inflammation and autoimmunity. © 2006 Elsevier GmbH. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.imbio.2006.11.008
dc.sourceScopus
dc.subjectApoptotic cells
dc.subjectAutoimmunity
dc.subjectC1q
dc.subjectDendritic cells
dc.subjectMacrophages
dc.subjectPhagocytosis
dc.subjectT cells
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1016/j.imbio.2006.11.008
dc.description.sourcetitleImmunobiology
dc.description.volume212
dc.description.issue4-5
dc.description.page245-252
dc.identifier.isiut000247738400003
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