Please use this identifier to cite or link to this item: https://doi.org/10.1002/pd.5985
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dc.titleA reasoned approach towards administering COVID-19 vaccines to pregnant women
dc.contributor.authorPramanick, Angsumita
dc.contributor.authorKanneganti, Abhiram
dc.contributor.authorWong, Jing Lin Jeslyn
dc.contributor.authorLi, Sarah Weiling
dc.contributor.authorDimri, Pooja Sharma
dc.contributor.authorMahyuddin, Aniza Puteri
dc.contributor.authorKumar, Sailesh
dc.contributor.authorIllanes, Sebastian Enrique
dc.contributor.authorChan, Jerry Kok Yen
dc.contributor.authorSu, Lin Lin
dc.contributor.authorBiswas, Arijit
dc.contributor.authorTambyah, Paul Anantharajah
dc.contributor.authorHuang, Ruby Yun-Ju
dc.contributor.authorMattar, Citra Nurfarah Zaini
dc.contributor.authorChoolani, Mahesh
dc.date.accessioned2023-12-20T06:54:31Z
dc.date.available2023-12-20T06:54:31Z
dc.date.issued2021-07
dc.identifier.citationPramanick, Angsumita, Kanneganti, Abhiram, Wong, Jing Lin Jeslyn, Li, Sarah Weiling, Dimri, Pooja Sharma, Mahyuddin, Aniza Puteri, Kumar, Sailesh, Illanes, Sebastian Enrique, Chan, Jerry Kok Yen, Su, Lin Lin, Biswas, Arijit, Tambyah, Paul Anantharajah, Huang, Ruby Yun-Ju, Mattar, Citra Nurfarah Zaini, Choolani, Mahesh (2021-07). A reasoned approach towards administering COVID-19 vaccines to pregnant women. PRENATAL DIAGNOSIS 41 (8) : 1018-1035. ScholarBank@NUS Repository. https://doi.org/10.1002/pd.5985
dc.identifier.issn0197-3851
dc.identifier.issn1097-0223
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/246506
dc.description.abstractThere are over 50 SARS-CoV-2 candidate vaccines undergoing Phase II and III clinical trials. Several vaccines have been approved by regulatory authorities and rolled out for use in different countries. Due to concerns of potential teratogenicity or adverse effect on maternal physiology, pregnancy has been a specific exclusion criterion for most vaccine trials with only two trials not excluding pregnant women. Thus, other than limited animal studies, gradually emerging development and reproductive toxicity data, and observational data from vaccine registries, there is a paucity of reliable information to guide recommendations for the safe vaccination of pregnant women. Pregnancy is a risk factor for severe COVID-19, especially in women with comorbidities, resulting in increased rates of preterm birth and maternal morbidity. We discuss the major SARS-CoV-2 vaccines, their mechanisms of action, efficacy, safety profile and possible benefits to the maternal-fetal dyad to create a rational approach towards maternal vaccination while anticipating and mitigating vaccine-related complications. Pregnant women with high exposure risks or co-morbidities predisposing to severe COVID-19 infection should be prioritised for vaccination. Those with risk factors for adverse effects should be counselled accordingly. It is essential to support patient autonomy by shared decision-making involving a risk-benefit discussion with the pregnant woman.
dc.language.isoen
dc.publisherWILEY
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectGenetics & Heredity
dc.subjectObstetrics & Gynecology
dc.subjectHEALTH-CARE WORKERS
dc.subjectUNITED-STATES
dc.subjectINFANTS BORN
dc.subjectANAPHYLAXIS
dc.subjectVACCINATION
dc.subjectINFECTION
dc.subjectTROPHOBLAST
dc.subjectCAMPAIGN
dc.subjectOUTCOMES
dc.subjectDISEASE
dc.typeReview
dc.date.updated2023-12-20T05:12:03Z
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentMEDICINE
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1002/pd.5985
dc.description.sourcetitlePRENATAL DIAGNOSIS
dc.description.volume41
dc.description.issue8
dc.description.page1018-1035
dc.published.statePublished
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