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https://doi.org/10.1038/s41541-023-00644-8
Title: | Recurrent Respiratory Papillomatosis (RRP)-Meta-analyses on the use of the HPV vaccine as adjuvant therapy | Authors: | Goon, Peter Sauzet, Odile Schuermann, Matthias Oppel, Felix Shao, SenYao Scholtz, Lars-Uwe Sudhoff, Holger Goerner, Martin |
Keywords: | Science & Technology Life Sciences & Biomedicine Immunology Medicine, Research & Experimental Research & Experimental Medicine RISK-FACTORS ONSET PREVALENCE INFECTION AGE L1 |
Issue Date: | 1-Apr-2023 | Publisher: | NATURE PORTFOLIO | Citation: | Goon, Peter, Sauzet, Odile, Schuermann, Matthias, Oppel, Felix, Shao, SenYao, Scholtz, Lars-Uwe, Sudhoff, Holger, Goerner, Martin (2023-04-01). Recurrent Respiratory Papillomatosis (RRP)-Meta-analyses on the use of the HPV vaccine as adjuvant therapy. NPJ VACCINES 8. ScholarBank@NUS Repository. https://doi.org/10.1038/s41541-023-00644-8 | Abstract: | Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease. Databases were accessed Nov and Dec 2021 [PubMed, Cochrane, Embase and Web of Science]. Main outcome measured was: Mean paired differences in the number of surgeries or recurrences per month. Analyses was performed using: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.) Our results found n = 38 patients, suitable for syntheses with one previous meta-analyses (4 published, 2 unpublished studies) n = 63, total of n = 101 patients. Analyses rendered an overall reduction of 0.123 recurrences or surgeries per month (95% confidence interval [0.064, 0.183]). Our meta-analyses concludes that HPV vaccine is a beneficial adjunct therapy alongside surgery | Source Title: | NPJ VACCINES | URI: | https://scholarbank.nus.edu.sg/handle/10635/246047 | ISSN: | 2059-0105 | DOI: | 10.1038/s41541-023-00644-8 |
Appears in Collections: | Staff Publications Elements |
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