Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fcvm.2023.1142078
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dc.title | Association of body mass index, metabolic health status and clinical outcomes in acute myocardial infarction patients: a national registry-based study | |
dc.contributor.author | Sia, Ching-Hui | |
dc.contributor.author | Ko, Junsuk | |
dc.contributor.author | Zheng, Huili | |
dc.contributor.author | Ho, Andrew Fu-Wah | |
dc.contributor.author | Foo, David | |
dc.contributor.author | Foo, Ling-Li | |
dc.contributor.author | Lim, Patrick Zhan-Yun | |
dc.contributor.author | Liew, Boon Wah | |
dc.contributor.author | Chai, Ping | |
dc.contributor.author | Yeo, Tiong-Cheng | |
dc.contributor.author | Yip, James WL | |
dc.contributor.author | Chua, Terrance | |
dc.contributor.author | Chan, Mark Yan-Yee | |
dc.contributor.author | Tan, Jack Wei Chieh | |
dc.contributor.author | Bulluck, Heerajnarain | |
dc.contributor.author | Hausenloy, Derek J | |
dc.date.accessioned | 2023-11-16T04:35:14Z | |
dc.date.available | 2023-11-16T04:35:14Z | |
dc.date.issued | 2023-06-26 | |
dc.identifier.citation | Sia, Ching-Hui, Ko, Junsuk, Zheng, Huili, Ho, Andrew Fu-Wah, Foo, David, Foo, Ling-Li, Lim, Patrick Zhan-Yun, Liew, Boon Wah, Chai, Ping, Yeo, Tiong-Cheng, Yip, James WL, Chua, Terrance, Chan, Mark Yan-Yee, Tan, Jack Wei Chieh, Bulluck, Heerajnarain, Hausenloy, Derek J (2023-06-26). Association of body mass index, metabolic health status and clinical outcomes in acute myocardial infarction patients: a national registry-based study. FRONTIERS IN CARDIOVASCULAR MEDICINE 10. ScholarBank@NUS Repository. https://doi.org/10.3389/fcvm.2023.1142078 | |
dc.identifier.issn | 2297-055X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/245992 | |
dc.description.abstract | Introduction: Obesity is an important risk factor for acute myocardial infarction (AMI), but the interplay between metabolic health and obesity on AMI mortality has been controversial. In this study, we aimed to elucidate the risk of short- and long-term all-cause mortality by obesity and metabolic health in AMI patients using data from a multi-ethnic national AMI registry. Methods: A total of 73,382 AMI patients from the national Singapore Myocardial Infarction Registry (SMIR) were included. These patients were classified into four groups based on the presence or absence of metabolic diseases, diabetes mellitus, hyperlipidaemia, and hypertension, and obesity: (1) metabolically-healthy-normal-weight (MHN); (2) metabolically-healthy-obese (MHO); (3) metabolically-unhealthy-normal-weight (MUN); and (4) metabolically-unhealthy-obese (MUO). Results: MHO patients had reduced unadjusted risk of all-cause in-hospital, 30-day, 1-year, 2-year, and 5-year mortality following the initial MI event. However, after adjusting for potential confounders, the protective effect from MHO on post-AMI mortality was lost. Furthermore, there was no reduced risk of recurrent MI or stroke within 1-year from onset of AMI by the MHO status. However, the risk of 1-year mortality was higher in female and Malay AMI patients with MHO compared to MHN even after adjusting for confounders. Conclusion: In AMI patients with or without metabolic diseases, the presence of obesity did not affect mortality. The exception to this finding were female and Malay MHO who had worse long-term AMI mortality outcomes when compared to MHN suggesting that the presence of obesity in female and Malay patients may confer worsened outcomes. | |
dc.language.iso | en | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cardiac & Cardiovascular Systems | |
dc.subject | Cardiovascular System & Cardiology | |
dc.subject | metabolism | |
dc.subject | acute myocardial infarction | |
dc.subject | metabolically healthy obesity (MHO) | |
dc.subject | cardiovascular risk | |
dc.subject | obesity paradox | |
dc.subject | AMI mortality | |
dc.subject | AMI prognosis | |
dc.subject | MHO paradox | |
dc.subject | CARDIOVASCULAR-DISEASE | |
dc.subject | RISK-FACTORS | |
dc.subject | ALL-CAUSE | |
dc.subject | OBESITY | |
dc.subject | MORTALITY | |
dc.type | Article | |
dc.date.updated | 2023-11-14T02:38:23Z | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.3389/fcvm.2023.1142078 | |
dc.description.sourcetitle | FRONTIERS IN CARDIOVASCULAR MEDICINE | |
dc.description.volume | 10 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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