Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/245925
DC Field | Value | |
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dc.title | A Mitochondrial Encoded Messenger at the Nucleus | |
dc.contributor.author | Yong, Cheryl Qian Ying | |
dc.contributor.author | Tang, Bor Luen | |
dc.date.accessioned | 2023-11-14T04:30:04Z | |
dc.date.available | 2023-11-14T04:30:04Z | |
dc.date.issued | 2018-08 | |
dc.identifier.citation | Yong, Cheryl Qian Ying, Tang, Bor Luen (2018-08). A Mitochondrial Encoded Messenger at the Nucleus. CELLS 7 (8). ScholarBank@NUS Repository. | |
dc.identifier.issn | 2073-4409 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/245925 | |
dc.description.abstract | Mitochondria–nucleus (mitonuclear) retrograde signaling via nuclear import of otherwise mitochondrial targeted factors occurs during mitochondrial unfolded protein response (UPRmt), a mechanism that counters mitochondrial and cellular stresses. Other than nuclear encoded proteins, mitochondrial DNA (mtDNA)-encoded peptides, such as humanin, are known to have important pro-survival and metabolic regulatory functions. A recent report has indicated that another mtDNA-encoded peptide, the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), could translocate into the nucleus upon stress induction. In the nucleus, MOTS-c binds to DNA and regulates the transcription of stress response genes in concert with other transcription factors. This is the first clear example of a mitochondria-derived peptide (MDP) acting in the nucleus to affect transcriptional responses to stress. Thus, MOTS-c may bear some characteristics of a ‘mitokine’ factor that mediates mitohormesis, influencing cell survival as well as organismal health and longevity. | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cell Biology | |
dc.subject | AMP-activated protein kinase (AMPK) | |
dc.subject | humanin | |
dc.subject | mitochondria | |
dc.subject | mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) | |
dc.subject | mitochondrial unfolded protein response (UPRmt) | |
dc.subject | ALZHEIMERS-DISEASE | |
dc.subject | REPERFUSION INJURY | |
dc.subject | PEPTIDE HUMANIN | |
dc.subject | STRESS-RESPONSE | |
dc.subject | LONGEVITY | |
dc.subject | AMPK | |
dc.subject | HOMEOSTASIS | |
dc.subject | REGULATORS | |
dc.subject | APOPTOSIS | |
dc.subject | ISCHEMIA | |
dc.type | Article | |
dc.date.updated | 2023-11-12T07:02:33Z | |
dc.contributor.department | DEAN'S OFFICE (NGS FOR INTGR SCI & ENGG) | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.sourcetitle | CELLS | |
dc.description.volume | 7 | |
dc.description.issue | 8 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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A Mitochondrial Encoded Messenger at the Nucleus. .pdf | 536.28 kB | Adobe PDF | OPEN | Published | View/Download |
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