SHAPE MEMORY MICROANCHORS WITH MAGNETIC GUIDANCE FOR INTRAVASCULAR MICROEMBOLIZATION

Abstract

Untethered intelligent microdevices through circulatory system show great potential for therapy but lack strategies to stably anchor them at the desired site in vascularized tissues to take actions. Here a shape memory functionalized biodegradable magnetic micro-anchor (SM2A) is developed to achieve magnetic guided endovascular localization through precisely controlled shape transformation. The SM2A comprises anisotropic polylactide-based microparticle embedded with superparamagnetic Fe3O4 nanoparticles, exhibiting thermally activated tunable shape recovery modes at a body-friendly temperature range to accomplished an efficient endovascular anchoring effect in both decellularized liver organ and rabbit ear embolization models. The SM2A can be anchored at the target micro-vessel, exhibiting a controlled radial expansion of the vessel wall. The SM2A is a promising platform to incorporate diagnostic or therapeutic agents for precision deployment and in-situ action.