Please use this identifier to cite or link to this item:
https://doi.org/10.1080/15548627.2018.1532261
DC Field | Value | |
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dc.title | Another longin SNARE for autophagosome-lysosome fusion-how does Ykt6 work? | |
dc.contributor.author | Yong, Cheryl Qian Ying | |
dc.contributor.author | Tang, Bor Luen | |
dc.date.accessioned | 2023-10-09T01:45:32Z | |
dc.date.available | 2023-10-09T01:45:32Z | |
dc.date.issued | 2019-02-01 | |
dc.identifier.citation | Yong, Cheryl Qian Ying, Tang, Bor Luen (2019-02-01). Another longin SNARE for autophagosome-lysosome fusion-how does Ykt6 work?. AUTOPHAGY 15 (2) : 352-357. ScholarBank@NUS Repository. https://doi.org/10.1080/15548627.2018.1532261 | |
dc.identifier.issn | 1554-8627 | |
dc.identifier.issn | 1554-8635 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/245188 | |
dc.description.abstract | Formation of the autolysosome involves SNARE-mediated autophagosome-lysosome fusion, which is mediated by a combination of the Qa SNARE STX17 (syntaxin 17), the Qbc SNARE SNAP29 and the R-SNAREs VAMP7/8. 2 very recent reports have now implicated another R-SNARE with a longin domain, YKT6, in this fusion process. Interestingly, these reports painted two different pictures of YKT6’s involvement. Studies in HeLa cells indicated that YKT6, acting independently of STX17, could form a separate SNARE complex with SNAP29 and another Qa SNARE to mediate autophagosome-lysosome fusion. Conversely, work in Drosophila larvae fat cells showed that while Ykt6 could form a SNARE complex with Snap29 and Syx17/Stx17, it is readily outcompeted by lysosomal Vamp7 in this regard. Moreover, its activity in autophagosome-lysosome fusion is not impaired by mutation of the supposedly critical ionic zero-layer residue from R to Q. In this regard, YKT6 may therefore act in a noncanonical way to regulate fusion. Here, we ponder on the fresh mechanistic perspectives on the final membrane fusion step of macroautophagy/autophagy offered by these new findings. Further, we propose another possible mechanism as to how YKT6 might act, which may provide some reconciliation to the differences observed. Abbreviations: LD: longin domain. | |
dc.language.iso | en | |
dc.publisher | TAYLOR & FRANCIS INC | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cell Biology | |
dc.subject | Autophagosome | |
dc.subject | autophagy | |
dc.subject | lysosome | |
dc.subject | SNARE | |
dc.subject | Syntaxin 17 (STX17) | |
dc.subject | YKT6 | |
dc.subject | PROTEIN YKT6 | |
dc.subject | HOPS COMPLEX | |
dc.subject | GOLGI | |
dc.subject | SYNTAXIN-5 | |
dc.subject | TRANSPORT | |
dc.subject | MATURATION | |
dc.subject | ENDOSOMES | |
dc.subject | CLEARANCE | |
dc.subject | MECHANISM | |
dc.subject | DOMAIN | |
dc.type | Article | |
dc.date.updated | 2023-10-07T02:08:28Z | |
dc.contributor.department | DEAN'S OFFICE (NGS FOR INTGR SCI & ENGG) | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1080/15548627.2018.1532261 | |
dc.description.sourcetitle | AUTOPHAGY | |
dc.description.volume | 15 | |
dc.description.issue | 2 | |
dc.description.page | 352-357 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Another longin SNARE for autophagosome-lysosome fusion-how does Ykt6 work.pdf | 663.85 kB | Adobe PDF | CLOSED | None | ||
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