Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.atherosclerosis.2005.10.002
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dc.titleThe V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women
dc.contributor.authorChan, E.
dc.contributor.authorTai, E.S.
dc.contributor.authorTan, C.S.
dc.contributor.authorChia, K.S.
dc.contributor.authorDeurenberg-Yap, M.
dc.contributor.authorChew, S.K.
dc.date.accessioned2011-07-25T07:17:17Z
dc.date.available2011-07-25T07:17:17Z
dc.date.issued2006
dc.identifier.citationChan, E., Tai, E.S., Tan, C.S., Chia, K.S., Deurenberg-Yap, M., Chew, S.K. (2006). The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women. Atherosclerosis 187 (2) : 309-315. ScholarBank@NUS Repository. https://doi.org/10.1016/j.atherosclerosis.2005.10.002
dc.identifier.issn00219150
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24517
dc.description.abstractPeroxisome proliferators activated receptor α (PPARα) regulates the transcription of several proteins involved in human lipoprotein metabolism. We screened the PPARA locus for polymorphisms in 20 unrelated subjects from each of three ethnic groups (Chinese, Malays and Asian Indians). Only the V227A polymorphism was observed. We genotyped 4248 subjects (2899 Chinese, 761 Malay and 588 Asian Indians) and found allele frequencies for the A227 allele of 0.04 in Chinese, 0.006 in Malays and 0.003 in Asian Indians. We examined the associations between this polymorphism and serum lipid concentrations in Chinese. In women, but not in men, the presence of the A227 allele was associated with lower serum concentrations of total cholesterol [5.38 mmol/l (95%CI: 5.22-5.54) versus 5.21 mmol/l (95%CI: 4.99-5.43), p = 0.047] and triglycerides [1.19 mmol/l (95%CI: 1.10-1.28) versus 1.09 mmol/l (95%CI: 0.98-1.21), p = 0.048]. We also found that the V227A polymorphism modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentration (p-value for interaction = 0.049). Our findings implicate PPARα in the lipid lowering associated with diets high in PUFA and suggests that genetic variation at the PPARA locus may determine the lipid response to changes in PUFA intake. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.atherosclerosis.2005.10.002
dc.sourceScopus
dc.subjectGene-nutrient interaction
dc.subjectLipids
dc.subjectPerosixome proliferator activated receptor α
dc.subjectPolymorphism
dc.subjectPolyunsaturated fatty acids
dc.typeArticle
dc.contributor.departmentCENTRE FOR MOLECULAR EPIDEMIOLOGY
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1016/j.atherosclerosis.2005.10.002
dc.description.sourcetitleAtherosclerosis
dc.description.volume187
dc.description.issue2
dc.description.page309-315
dc.identifier.isiut000239368000010
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