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Title: Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study
Authors: Orgeas, C.C.
Sanner, K.
Hall, P.
Persson, I.
Wedren, S.
Dickman, P.W.
Czene, K.
Conner, P.
Holte, J.
Nilsson, S.J.
Sundfeldt, K.
Chia, K.S. 
Keywords: breast cancer
hormone infertility treatment
Issue Date: 2009
Citation: Orgeas, C.C., Sanner, K., Hall, P., Persson, I., Wedren, S., Dickman, P.W., Czene, K., Conner, P., Holte, J., Nilsson, S.J., Sundfeldt, K., Chia, K.S. (2009). Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study. American Journal of Obstetrics and Gynecology 200 (1). ScholarBank@NUS Repository.
Abstract: Objective: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer. Study Design: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer. Results: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67). Conclusion: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer. © 2009 Mosby, Inc. All rights reserved.
Source Title: American Journal of Obstetrics and Gynecology
ISSN: 00029378
DOI: 10.1016/j.ajog.2008.08.066
Appears in Collections:Staff Publications

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