Please use this identifier to cite or link to this item:
Title: Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
Authors: Balasubramanian, S.K.
Yu, L.E. 
Jittiwat, J. 
Ong, W.-Y. 
Manikandan, J. 
Ong, C.-N. 
Keywords: Biodistribution
Gold nanoparticles
Intravenous injection
Issue Date: 2010
Citation: Balasubramanian, S.K., Yu, L.E., Jittiwat, J., Ong, W.-Y., Manikandan, J., Ong, C.-N. (2010). Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats. Biomaterials 31 (8) : 2034-2042. ScholarBank@NUS Repository.
Abstract: Biodistribution of gold nanoparticles (AuNPs) in more than 25 organs were examined on 1 day, 1 week, 1 month and 2 months after a single intravenous (i.v.) injection in rats. Au was rapidly and consistently accumulated in liver (49.4 ± 50.4-72.2 ± 40.5 ng/g) and spleen (8.4 ± 5.0-9.5 ± 6.4 ng/g) throughout the entire timeframe of the study (2 months). Significant accumulation of Au in kidney (up to 5.5 ± 2.5 ng/g) and testis (up to 0.6 ± 0.1 ng/g) occurred from 1 month post-injection when Au level in urine and feces decreased. Significant increase of Au in blood occurred 2 months after injection, coincident with the delayed accumulation in kidney. Au accumulation in lungs was found at 1 day post-injection but decreased within a week. No accumulation of Au was found in the brain. Microarray results of liver and spleen point to significant effects on genes related to detoxification, lipid metabolism, cell cycle, defense response, and circadian rhythm. These results demonstrate that significant biodistribution of Au occurs in the body over 2 months after a single i.v. injection of AuNPs, accompanied by gene expression changes in target organs. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2009.11.079
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Oct 21, 2021


checked on Oct 21, 2021

Page view(s)

checked on Oct 14, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.