Please use this identifier to cite or link to this item:
https://doi.org/10.1093/femsml/uqab002
DC Field | Value | |
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dc.title | The composition and function of Enterococcus faecalis membrane vesicles. | |
dc.contributor.author | Afonina, Irina | |
dc.contributor.author | Tien, Brenda | |
dc.contributor.author | Nair, Zeus | |
dc.contributor.author | Matysik, Artur | |
dc.contributor.author | Lam, Ling Ning | |
dc.contributor.author | Veleba, Mark | |
dc.contributor.author | Jie, Augustine Koh Jing | |
dc.contributor.author | Rashid, Rafi | |
dc.contributor.author | Cazenave-Gassiot, Amaury | |
dc.contributor.author | Wenk, Marcus | |
dc.contributor.author | Wai, Sun Nyunt | |
dc.contributor.author | Kline, Kimberly A | |
dc.date.accessioned | 2023-07-18T03:41:14Z | |
dc.date.available | 2023-07-18T03:41:14Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Afonina, Irina, Tien, Brenda, Nair, Zeus, Matysik, Artur, Lam, Ling Ning, Veleba, Mark, Jie, Augustine Koh Jing, Rashid, Rafi, Cazenave-Gassiot, Amaury, Wenk, Marcus, Wai, Sun Nyunt, Kline, Kimberly A (2021). The composition and function of Enterococcus faecalis membrane vesicles.. Microlife 2 : uqab002-. ScholarBank@NUS Repository. https://doi.org/10.1093/femsml/uqab002 | |
dc.identifier.issn | 2633-6693 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/243175 | |
dc.description.abstract | Membrane vesicles (MVs) contribute to various biological processes in bacteria, including virulence factor delivery, antimicrobial resistance, host immune evasion and cross-species communication. MVs are frequently released from the surface of both Gram-negative and Gram-positive bacteria during growth. In some Gram-positive bacteria, genes affecting MV biogenesis have been identified, but the mechanism of MV formation is unknown. In Enterococcus faecalis, a causative agent of life-threatening bacteraemia and endocarditis, neither mechanisms of MV formation nor their role in virulence has been examined. Since MVs of many bacterial species are implicated in host-pathogen interactions, biofilm formation, horizontal gene transfer, and virulence factor secretion in other species, we sought to identify, describe and functionally characterize MVs from E. faecalis. Here, we show that E. faecalis releases MVs that possess unique lipid and protein profiles, distinct from the intact cell membrane and are enriched in lipoproteins. MVs of E. faecalis are specifically enriched in unsaturated lipids that might provide membrane flexibility to enable MV formation, providing the first insights into the mechanism of MV formation in this Gram-positive organism. | |
dc.publisher | Oxford University Press (OUP) | |
dc.source | Elements | |
dc.subject | Enterococcus faecalis | |
dc.subject | NF-kB signaling | |
dc.subject | horizontal gene transfer | |
dc.subject | lipidomics | |
dc.subject | membrane vesicles | |
dc.subject | proteomics | |
dc.type | Article | |
dc.date.updated | 2023-07-17T06:59:23Z | |
dc.contributor.department | NUS GRADUATE SCHOOL | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1093/femsml/uqab002 | |
dc.description.sourcetitle | Microlife | |
dc.description.volume | 2 | |
dc.description.page | uqab002- | |
dc.published.state | Published online | |
Appears in Collections: | Staff Publications Elements |
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uqab002.pdf | Published version | 3.61 MB | Adobe PDF | OPEN | None | View/Download |
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