Please use this identifier to cite or link to this item:
https://doi.org/10.3390/cells9020279
DC Field | Value | |
---|---|---|
dc.title | Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome | |
dc.contributor.author | Hsieh, CY | |
dc.contributor.author | Li, LH | |
dc.contributor.author | Lam, Y | |
dc.contributor.author | Fang, Z | |
dc.contributor.author | Gan, CH | |
dc.contributor.author | Rao, YK | |
dc.contributor.author | Chiu, HW | |
dc.contributor.author | Wong, WT | |
dc.contributor.author | Ju, TC | |
dc.contributor.author | Chen, FH | |
dc.contributor.author | Chernikov, OV | |
dc.contributor.author | Liu, ML | |
dc.contributor.author | Hsu, CH | |
dc.contributor.author | Hua, KF | |
dc.date.accessioned | 2023-07-10T08:45:01Z | |
dc.date.available | 2023-07-10T08:45:01Z | |
dc.date.issued | 2020-01-23 | |
dc.identifier.citation | Hsieh, CY, Li, LH, Lam, Y, Fang, Z, Gan, CH, Rao, YK, Chiu, HW, Wong, WT, Ju, TC, Chen, FH, Chernikov, OV, Liu, ML, Hsu, CH, Hua, KF (2020-01-23). Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome. Cells 9 (2) : E279-. ScholarBank@NUS Repository. https://doi.org/10.3390/cells9020279 | |
dc.identifier.issn | 2073-4409 | |
dc.identifier.issn | 2073-4409 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/242991 | |
dc.description.abstract | Gouty arthritis results from the generation of uric acid crystals within the joints. These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, which is involved in chronic inflammatory diseases, including gouty arthritis. This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo. 4-HAB dose-dependently reduced the release of interleukin (IL)-1β, IL-18, active caspase-1 and apoptosis-associated speck-like protein (ASC) in uric acid crystals-activated macrophages. In a mechanistic study, 4-HAB was shown to inhibit uric acid crystals-induced mitochondrial damage, lysosomal rupture and ASC oligomerization. Additionally, 4-HAB inhibited the NLRP3 inflammasome through Sirt1-dependent autophagy induction. Furthermore, the anti-inflammatory properties of 4-HAB were confirmed in a mouse model of uric acid crystals-mediated peritonitis by the reduced levels of neutrophil influx, IL-1β, active caspase-1, IL-6 and MCP-1 in lavage fluids. In conclusion, 4-HAB attenuates gouty inflammation, in part by attenuating activation of the NLRP3 inflammasome through the Sirt1/autophagy induction pathway. | |
dc.publisher | MDPI AG | |
dc.source | Elements | |
dc.subject | 4-hydroxy auxarconjugatin B | |
dc.subject | NLRP3 inflammasome | |
dc.subject | autophagy | |
dc.subject | gouty inflammation | |
dc.subject | mitochondria | |
dc.subject | Animals | |
dc.subject | Arthritis, Gouty | |
dc.subject | Autophagy | |
dc.subject | CARD Signaling Adaptor Proteins | |
dc.subject | Cell Line | |
dc.subject | Disease Models, Animal | |
dc.subject | Humans | |
dc.subject | Inflammasomes | |
dc.subject | Inflammation | |
dc.subject | Lipopolysaccharides | |
dc.subject | Lysosomes | |
dc.subject | Macrophages | |
dc.subject | Male | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mitochondria | |
dc.subject | Models, Biological | |
dc.subject | NLR Family, Pyrin Domain-Containing 3 Protein | |
dc.subject | Organelle Biogenesis | |
dc.subject | Protein Multimerization | |
dc.subject | Pyrroles | |
dc.subject | Sirtuin 1 | |
dc.type | Article | |
dc.date.updated | 2023-07-10T08:04:25Z | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.3390/cells9020279 | |
dc.description.sourcetitle | Cells | |
dc.description.volume | 9 | |
dc.description.issue | 2 | |
dc.description.page | E279- | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Infl.pdf | 2.3 MB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.