Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroimage.2009.01.036
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dc.titleCognitive function and brain structure correlations in healthy elderly East Asians
dc.contributor.authorChee, M.W.L.
dc.contributor.authorChen, K.H.M.
dc.contributor.authorZheng, H.
dc.contributor.authorChan, K.P.L.
dc.contributor.authorIsaac, V.
dc.contributor.authorSim, S.K.Y.
dc.contributor.authorChuah, L.Y.M.
dc.contributor.authorSchuchinsky, M.
dc.contributor.authorFischl, B.
dc.contributor.authorNg, T.P.
dc.date.accessioned2011-07-25T02:10:38Z
dc.date.available2011-07-25T02:10:38Z
dc.date.issued2009
dc.identifier.citationChee, M.W.L., Chen, K.H.M., Zheng, H., Chan, K.P.L., Isaac, V., Sim, S.K.Y., Chuah, L.Y.M., Schuchinsky, M., Fischl, B., Ng, T.P. (2009). Cognitive function and brain structure correlations in healthy elderly East Asians. NeuroImage 46 (1) : 257-269. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroimage.2009.01.036
dc.identifier.issn10538119
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24284
dc.description.abstractWe investigated the effect of age and health variables known to modulate cognitive aging on several measures of cognitive performance and brain volume in a cohort of healthy, non-demented persons of Chinese descent aged between 55 and 86 years. 248 subjects contributed combined neuropsychological, MR imaging, health and socio-demographic information. Speed of processing showed the largest age-related decline. Education and plasma homocysteine levels modulated age-related decline in cognitive performance. Total cerebral volume declined at an annual rate of 0.4%/yr. Gray and white matter volume loss was comparable in magnitude. Regionally, there was relatively greater volume loss in the lateral prefrontal cortex bilaterally, around the primary visual cortex as well as bilateral superior parietal cortices. Speed of processing showed significant positive correlation with gray matter volume in several frontal, parietal and midline occipital regions bilaterally. In spite of differences in diet, lifestyle and culture, these findings are broadly comparable to studies conducted in Caucasian populations and suggest generalizability of processes involved in age-related decline in cognition and brain volume. © 2009 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neuroimage.2009.01.036
dc.sourceScopus
dc.subjectCognitive aging
dc.subjectCohort studies
dc.subjectCortical thickness
dc.subjectMRI
dc.subjectVolumetry
dc.subjectWhite matter
dc.typeArticle
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.neuroimage.2009.01.036
dc.description.sourcetitleNeuroImage
dc.description.volume46
dc.description.issue1
dc.description.page257-269
dc.identifier.isiut000265723800028
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