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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2005.04.013
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dc.titleHypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer
dc.contributor.authorDu, H.
dc.contributor.authorBay, B.-H.
dc.contributor.authorMahendran, R.
dc.contributor.authorOlivo, M.
dc.date.accessioned2011-07-19T10:13:42Z
dc.date.available2011-07-19T10:13:42Z
dc.date.issued2006
dc.identifier.citationDu, H., Bay, B.-H., Mahendran, R., Olivo, M. (2006). Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer. Cancer Letters 235 (2) : 202-208. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.04.013
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24204
dc.description.abstractCytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upregulated in PDT-treated CNE-2 poorly differentiated cells but not in HK1 well differentiated cells. In vivo, IL-6 mRNA expression was elevated in PDT-treated CNE-2 tumors but not in HK1 tumors. In conclusion, the study elucidated that the cell type, degree of histological differentiation and the basal expression of the cytokine influence the cytokine response following PDT. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2005.04.013
dc.sourceScopus
dc.subjectCNE-2
dc.subjectCytokines
dc.subjectHypericin
dc.subjectIL-6
dc.subjectInterleukin-6
dc.subjectNasopharyngeal cancer
dc.subjectNPC
dc.subjectPDT
dc.subjectPhotodynamic therapy
dc.typeArticle
dc.contributor.departmentSURGERY
dc.contributor.departmentANATOMY
dc.description.doi10.1016/j.canlet.2005.04.013
dc.description.sourcetitleCancer Letters
dc.description.volume235
dc.description.issue2
dc.description.page202-208
dc.identifier.isiut000237619500004
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