Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.62.4.17
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dc.titleRapid Myopic Progression in Childhood Is Associated With Teenage High Myopia
dc.contributor.authorLanca, Carla
dc.contributor.authorFoo, Li-Lian
dc.contributor.authorAng, Marcus
dc.contributor.authorTan, Chuen-Seng
dc.contributor.authorKathrani, Biten
dc.contributor.authorHtoon, Hla Myint
dc.contributor.authorTan, Donald
dc.contributor.authorHoang, Quan
dc.contributor.authorBrennan, Noel
dc.contributor.authorSaw, Seang-Mei
dc.contributor.authorSabanayagam, Charumathi
dc.date.accessioned2023-06-14T09:06:56Z
dc.date.available2023-06-14T09:06:56Z
dc.date.issued2021-04-01
dc.identifier.citationLanca, Carla, Foo, Li-Lian, Ang, Marcus, Tan, Chuen-Seng, Kathrani, Biten, Htoon, Hla Myint, Tan, Donald, Hoang, Quan, Brennan, Noel, Saw, Seang-Mei, Sabanayagam, Charumathi (2021-04-01). Rapid Myopic Progression in Childhood Is Associated With Teenage High Myopia. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 62 (4). ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.62.4.17
dc.identifier.issn0146-0404,1552-5783
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/242001
dc.description.abstractPURPOSE. The purpose of this study was to evaluate the association of childhood progression of spherical equivalent (SE) with high myopia (HM) in teenagers in the Singapore Cohort of Risk factors for Myopia (SCORM). METHODS. We included 928 SCORM children followed over a mean follow-up of 6.9 ± 1.0 years from baseline (6-11 years old) until their teenage years (12-19 years old). Cycloplegic autorefraction and axial length (AL) measurements were performed yearly. The outcomes in teenagers were HM (SE ≤ −5 diopter [D)], AL ≥ 25 mm, SE and AL. Three-year SE and AL progression in childhood and baseline SE and AL with outcomes were evaluated using multivariable logistic or linear regression models, with predictive performance of risk factors assessed using the area under the curve (AUC). RESULTS. At the last visit, 9.8% of teenagers developed HM and 22.7% developed AL ≥ 25 mm. In multivariate regression analyses, every −0.3 D/year increase in 3-year SE progression and every 0.2 mm/year increase in 3-year AL progression were associated with a −1.14 D greater teenage SE and 0.52 mm greater teenage AL (P values < 0.001). The AUC (95% confidence interval [CI]) of a combination of 3-year SE progression and baseline SE for teenage HM was 0.97 (95% CI = 0.95 - 0.98). The AUC of 3-year AL progression and baseline AL for teenage AL ≥ 25 mm was 0.91 (95% CI = 0.89 - 0.94). CONCLUSIONS. Three-year myopia progression in childhood combined with baseline SE or AL were good predictors of teenage HM. Clinicians may use this combination of factors to guide timing of interventions, potentially reducing the risk of HM later in life.
dc.language.isoen
dc.publisherASSOC RESEARCH VISION OPHTHALMOLOGY INC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectOphthalmology
dc.subjectmyopia
dc.subjectprogression
dc.subjectteenagers
dc.subjectCHOROIDAL NEOVASCULARIZATION
dc.subjectVISUAL IMPAIRMENT
dc.subjectRISK
dc.subjectPREVALENCE
dc.subjectNEARWORK
dc.subjectCHILDREN
dc.subjectONSET
dc.typeArticle
dc.date.updated2023-06-06T02:33:12Z
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1167/iovs.62.4.17
dc.description.sourcetitleINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
dc.description.volume62
dc.description.issue4
dc.published.statePublished
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