Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cell.2022.10.023
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dc.titleA Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization
dc.contributor.authorSingh, Tulika
dc.contributor.authorHwang, Kwan-Ki
dc.contributor.authorMiller, Andrew S
dc.contributor.authorJones, Rebecca L
dc.contributor.authorLopez, Cesar A
dc.contributor.authorDulson, Sarah J
dc.contributor.authorGiuberti, Camila
dc.contributor.authorGladden, Morgan A
dc.contributor.authorMiller, Itzayana
dc.contributor.authorWebster, Helen S
dc.contributor.authorEudailey, Joshua A
dc.contributor.authorLuo, Kan
dc.contributor.authorVon Holle, Tarra
dc.contributor.authorEdwards, Robert J
dc.contributor.authorValencia, Sarah
dc.contributor.authorBurgomaster, Katherine E
dc.contributor.authorZhang, Summer
dc.contributor.authorMangold, Jesse F
dc.contributor.authorTu, Joshua J
dc.contributor.authorDennis, Maria
dc.contributor.authorAlam, S Munir
dc.contributor.authorPremkumar, Lakshmanane
dc.contributor.authorDietze, Reynaldo
dc.contributor.authorPierson, Theodore C
dc.contributor.authorOoi, Eng Eong
dc.contributor.authorLazear, Helen M
dc.contributor.authorKuhn, Richard J
dc.contributor.authorPermar, Sallie R
dc.contributor.authorBonsignori, Mattia
dc.date.accessioned2023-06-12T08:59:56Z
dc.date.available2023-06-12T08:59:56Z
dc.date.issued2022-12-08
dc.identifier.citationSingh, Tulika, Hwang, Kwan-Ki, Miller, Andrew S, Jones, Rebecca L, Lopez, Cesar A, Dulson, Sarah J, Giuberti, Camila, Gladden, Morgan A, Miller, Itzayana, Webster, Helen S, Eudailey, Joshua A, Luo, Kan, Von Holle, Tarra, Edwards, Robert J, Valencia, Sarah, Burgomaster, Katherine E, Zhang, Summer, Mangold, Jesse F, Tu, Joshua J, Dennis, Maria, Alam, S Munir, Premkumar, Lakshmanane, Dietze, Reynaldo, Pierson, Theodore C, Ooi, Eng Eong, Lazear, Helen M, Kuhn, Richard J, Permar, Sallie R, Bonsignori, Mattia (2022-12-08). A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization. CELL 185 (25) : 4826-+. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cell.2022.10.023
dc.identifier.issn0092-8674
dc.identifier.issn1097-4172
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/241883
dc.description.abstractCongenital Zika virus (ZIKV) infection results in neurodevelopmental deficits in up to 14% of infants born to ZIKV-infected mothers. Neutralizing antibodies are a critical component of protective immunity. Here, we demonstrate that plasma IgM contributes to ZIKV immunity in pregnancy, mediating neutralization up to 3 months post-symptoms. From a ZIKV-infected pregnant woman, we isolated a pentameric ZIKV-specific IgM (DH1017.IgM) that exhibited ultrapotent ZIKV neutralization dependent on the IgM isotype. DH1017.IgM targets an envelope dimer epitope within domain II. The epitope arrangement on the virion is compatible with concurrent engagement of all ten antigen-binding sites of DH1017.IgM, a solution not available to IgG. DH1017.IgM protected mice against viremia upon lethal ZIKV challenge more efficiently than when expressed as an IgG. Our findings identify a role for antibodies of the IgM isotype in protection against ZIKV and posit DH1017.IgM as a safe and effective candidate immunotherapeutic, particularly during pregnancy.
dc.language.isoen
dc.publisherCELL PRESS
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectBiochemistry & Molecular Biology
dc.subjectCell Biology
dc.subjectIMMUNOGLOBULIN-M ANTIBODIES
dc.subjectDENGUE
dc.subjectPROTECTION
dc.subjectVACCINE
dc.subjectMICROSCOPY
dc.subjectCHALLENGE
dc.subjectPERSISTENCE
dc.subjectINFECTION
dc.subjectEFFICACY
dc.subjectBROAD
dc.typeArticle
dc.date.updated2023-06-06T01:19:46Z
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.cell.2022.10.023
dc.description.sourcetitleCELL
dc.description.volume185
dc.description.issue25
dc.description.page4826-+
dc.published.statePublished
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