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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.phrs.2023.106756
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dc.titleThe role of tumor-derived extracellular vesicles containing noncoding RNAs in mediating immune cell function and its implications from bench to bedside
dc.contributor.authorLiu, CG
dc.contributor.authorChen, J
dc.contributor.authorGoh, RMWJ
dc.contributor.authorLiu, YX
dc.contributor.authorWang, L
dc.contributor.authorMa, Z
dc.date.accessioned2023-06-09T09:43:04Z
dc.date.available2023-06-09T09:43:04Z
dc.date.issued2023-05-01
dc.identifier.citationLiu, CG, Chen, J, Goh, RMWJ, Liu, YX, Wang, L, Ma, Z (2023-05-01). The role of tumor-derived extracellular vesicles containing noncoding RNAs in mediating immune cell function and its implications from bench to bedside. Pharmacological Research 191 : 106756-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.phrs.2023.106756
dc.identifier.issn1043-6618
dc.identifier.issn1096-1186
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/241807
dc.description.abstractExtracellular vesicles (EVs) are membrane-encapsulated vesicles released by almost all cell types, which participate in intercellular communication by delivering different types of molecular cargoes, such as non-coding RNAs (ncRNAs). Accumulating evidence suggests that tumor-derived EVs act as a bridge for intercellular crosstalk between tumor cells and surrounding cells, including immune cells. Tumor-derived EVs containing ncRNAs (TEV-ncRNAs) mediate intercellular crosstalk to manipulate immune responses and affect the malignant phenotypes of cancer cells. In this review, we summarize the double-edged roles and the underlying mechanisms of TEV-ncRNAs in regulating innate and adaptive immune cells. We also highlight the advantages of using TEV-ncRNAs in liquid biopsies for cancer diagnosis and prognosis. Moreover, we outline the use of engineered EVs to deliver ncRNAs and other therapeutic agents for cancer therapy.
dc.publisherElsevier BV
dc.sourceElements
dc.subjectCancer therapy
dc.subjectExtracellular vesicles
dc.subjectNon-coding RNAs
dc.subjectTumor immunity
dc.subjectExtracellular Vesicles
dc.subjectRNA, Untranslated
dc.subjectImmunity, Innate
dc.subjectCell Communication
dc.typeArticle
dc.date.updated2023-06-06T07:24:59Z
dc.contributor.departmentMEDICINE
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1016/j.phrs.2023.106756
dc.description.sourcetitlePharmacological Research
dc.description.volume191
dc.description.page106756-
dc.published.statePublished
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