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https://doi.org/10.1038/s41467-020-14576-7
DC Field | Value | |
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dc.title | Weak functional group interactions revealed through metal-free active template rotaxane synthesis | |
dc.contributor.author | Tian, Chong | |
dc.contributor.author | Fielden, Stephen DP | |
dc.contributor.author | Whitehead, George FS | |
dc.contributor.author | Vitorica-Yrezabal, Inigo J | |
dc.contributor.author | Leigh, David A | |
dc.date.accessioned | 2023-06-08T12:14:40Z | |
dc.date.available | 2023-06-08T12:14:40Z | |
dc.date.issued | 2020-02-06 | |
dc.identifier.citation | Tian, Chong, Fielden, Stephen DP, Whitehead, George FS, Vitorica-Yrezabal, Inigo J, Leigh, David A (2020-02-06). Weak functional group interactions revealed through metal-free active template rotaxane synthesis. NATURE COMMUNICATIONS 11 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-14576-7 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/241763 | |
dc.description.abstract | Modest functional group interactions can play important roles in molecular recognition, catalysis and self-assembly. However, weakly associated binding motifs are often difficult to characterize. Here, we report on the metal-free active template synthesis of [2]rotaxanes in one step, up to 95% yield and >100:1 rotaxane:axle selectivity, from primary amines, crown ethers and a range of C=O, C=S, S(=O)2 and P=O electrophiles. In addition to being a simple and effective route to a broad range of rotaxanes, the strategy enables 1:1 interactions of crown ethers with various functional groups to be characterized in solution and the solid state, several of which are too weak — or are disfavored compared to other binding modes — to be observed in typical host–guest complexes. The approach may be broadly applicable to the kinetic stabilization and characterization of other weak functional group interactions. | |
dc.language.iso | en | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | INTERLOCKED MOLECULES | |
dc.subject | CROWN-ETHER | |
dc.subject | AMINOLYSIS | |
dc.subject | COMPLEXES | |
dc.subject | 18-CROWN-6 | |
dc.subject | MECHANISM | |
dc.subject | CATALYSIS | |
dc.subject | KINETICS | |
dc.subject | CATENANES | |
dc.subject | TRANSPORT | |
dc.type | Article | |
dc.date.updated | 2023-06-06T01:41:31Z | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1038/s41467-020-14576-7 | |
dc.description.sourcetitle | NATURE COMMUNICATIONS | |
dc.description.volume | 11 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Weak functional group interactions revealed through metal-free active template rotaxane synthesis.pdf | 1.51 MB | Adobe PDF | OPEN | None | View/Download |
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