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Title: | THE ROLE OF STRESS RESPONSE SIGNALING PATHWAYS THAT GOVERN DENDRITE PRUNING IN DROSOPHILA SENSORY NEURONS | Authors: | CHEW LIANG YUH | ORCID iD: | orcid.org/0000-0002-6821-0595 | Keywords: | Nrf2-Keap1 pathway, CncC, ecdysone signaling, AMPK kinase, dendrite pruning, insulin pathway | Issue Date: | 6-Jan-2023 | Citation: | CHEW LIANG YUH (2023-01-06). THE ROLE OF STRESS RESPONSE SIGNALING PATHWAYS THAT GOVERN DENDRITE PRUNING IN DROSOPHILA SENSORY NEURONS. ScholarBank@NUS Repository. | Abstract: | Neuronal pruning is a crucial developmental step of the nervous system to remove unnecessary dendrites or axons. The evolutionarily conserved Nrf2-Keap1 pathway is a key antioxidant response pathway that protects cells or organisms against devastating effects of oxidative stress. Here, I demonstrate a cell-autonomous role of the Nrf2-Keap1pathway in governing dendrite pruning in Drosophila sensory neurons. Importantly, Nrf2-Keap1 signaling is activated downstream of the steroid hormone ecdysone via nuclear translocation of CncC(Drosophila homolog of Nrf2). Interestingly, Nrf2-Keap1 signaling regulates dendrite pruning independently of its canonical antioxidant response pathway, but instead through proteasomal degradation. Next, I show that the metabolic regulator AMP-activated protein kinase (AMPK) activates Nrf2-Keap1 pathway via inhibition of the insulin pathway to promote dendrite pruning. | URI: | https://scholarbank.nus.edu.sg/handle/10635/241464 |
Appears in Collections: | Ph.D Theses (Open) |
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