Please use this identifier to cite or link to this item: https://doi.org/10.1002/eji.202149488
DC FieldValue
dc.titleSoluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol-associated disease etiology
dc.contributor.authorWeigand, K
dc.contributor.authorPeschel, G
dc.contributor.authorGrimm, J
dc.contributor.authorLuu, K
dc.contributor.authorSchacherer, D
dc.contributor.authorWiest, R
dc.contributor.authorMüller, M
dc.contributor.authorSchwarz, H
dc.contributor.authorBuechler, C
dc.date.accessioned2023-05-02T07:53:09Z
dc.date.available2023-05-02T07:53:09Z
dc.date.issued2022-04-01
dc.identifier.citationWeigand, K, Peschel, G, Grimm, J, Luu, K, Schacherer, D, Wiest, R, Müller, M, Schwarz, H, Buechler, C (2022-04-01). Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol-associated disease etiology. European Journal of Immunology 52 (4) : 633-645. ScholarBank@NUS Repository. https://doi.org/10.1002/eji.202149488
dc.identifier.issn0014-2980
dc.identifier.issn1521-4141
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/239107
dc.description.abstractDefective T-cell functions play a role in the persistence of HCV infection. Activated T cells express CD137, which costimulates antivirus T-cell responses, and this activity is antagonized by soluble CD137 (sCD137). Here, we show that in sera of 81 patients with chronic HCV, sCD137 levels did not correlate with measures of viral infection, and did not decline after virus eradication using direct-acting antivirals. Thus, serum sCD137 was similar in patients infected with HCV and in uninfected controls. Of note, in HCV patients with liver cirrhosis and patients with mostly alcohol-associated liver cirrhosis, sCD137 was increased. A negative association of sCD137 and albumin existed in both cohorts. sCD137 concentrations were similar in hepatic and portal vein blood excluding the liver as the origin of higher levels. Recombinant sCD137 reduced Th1 and Th2 but not Th17 cell polarization in vitro, and accordingly lowered IFN-γ, TNF, and IL-13 in cell media. Serum sCD137 is associated with inflammatory states, and positively correlated with serum TNF in cirrhotic HCV patients following virus eradication. Our study argues against a role of sCD137 in HCV infection and suggests a function of sCD137 in liver cirrhosis, which yet has to be defined.
dc.publisherWiley
dc.sourceElements
dc.subjectDirect-acting antivirals
dc.subjectFoxp3
dc.subjectMELD score
dc.subjectTNF
dc.subjectliver cirrhosis
dc.subjectAntiviral Agents
dc.subjectBiomarkers
dc.subjectHepacivirus
dc.subjectHepatitis C
dc.subjectHepatitis C, Chronic
dc.subjectHumans
dc.subjectLiver Cirrhosis
dc.typeArticle
dc.date.updated2023-05-02T03:41:52Z
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1002/eji.202149488
dc.description.sourcetitleEuropean Journal of Immunology
dc.description.volume52
dc.description.issue4
dc.description.page633-645
dc.published.statePublished
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Weigand 2021 - sCD137 in hepatitis.pdf1.15 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.