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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jpsychires.2020.03.013
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dc.titlePlasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia
dc.contributor.authorHo, New Fei
dc.contributor.authorTng, Jordon Xin Jie
dc.contributor.authorWang, Mingyuan
dc.contributor.authorChen, Guoyang
dc.contributor.authorSubbaraju, Vigneshwaran
dc.contributor.authorShukor, Suhailah
dc.contributor.authorNg, Desiree Si Xian
dc.contributor.authorTan, Bhing-Leet
dc.contributor.authorPuang, Shu Juan
dc.contributor.authorKho, Sok-Hong
dc.contributor.authorSiew, Rachel Wan En
dc.contributor.authorSin, Gwen Li
dc.contributor.authorEu, Pui Wai
dc.contributor.authorZhou, Juan
dc.contributor.authorSng, Judy Chia Ghee
dc.contributor.authorSim, Kang
dc.contributor.authorMedalia, Alice
dc.date.accessioned2023-03-23T08:18:09Z
dc.date.available2023-03-23T08:18:09Z
dc.date.issued2020-07-01
dc.identifier.citationHo, New Fei, Tng, Jordon Xin Jie, Wang, Mingyuan, Chen, Guoyang, Subbaraju, Vigneshwaran, Shukor, Suhailah, Ng, Desiree Si Xian, Tan, Bhing-Leet, Puang, Shu Juan, Kho, Sok-Hong, Siew, Rachel Wan En, Sin, Gwen Li, Eu, Pui Wai, Zhou, Juan, Sng, Judy Chia Ghee, Sim, Kang, Medalia, Alice (2020-07-01). Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia. JOURNAL OF PSYCHIATRIC RESEARCH 126 : 122-133. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpsychires.2020.03.013
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/238363
dc.description.abstractCognitive remediation (CR) is predicated on principles of neuroplasticity, but the actual molecular and neurocircuitry changes underlying cognitive change in individuals with impaired neuroplastic processes is poorly understood. The present study examined epigenetic-neurocircuitry-behavioral outcome measures in schizophrenia, before and after participating in a CR program that targeted higher-order cognitive functions. Outcome measures included DNA methylation of genes central to synaptic plasticity (CpG sites of Reelin promoter and BDNF promoter) from buccal swabs, resting-state functional brain connectivity and topological network efficiency, and global scores of a cognitive battery from 35 inpatients in a rehabilitative ward (18 CR, 17 non-CR) with similar premorbid IQ to 15 healthy controls. Baseline group differences between healthy controls and schizophrenia, group-by-time effects of CR in schizophrenia, and associations between the outcome measures were tested. Baseline functional connectivity abnormalities within the frontal, fronto-temporal and fronto-parietal regions, and trending decreases in global efficiency, but not DNA methylation, were found in schizophrenia; the frontal and fronto-temporal connectivity, and global efficiency correlated with global cognitive performance across all individuals. Notably, CR resulted in differential changes in Reelin promoter CpG methylation levels, altered within-frontal and fronto-temporal functional connectivity, increasing global efficiency and improving cognitive performance in schizophrenia, when compared to non-CR. In the CR inpatients, positive associations between the micro to macro measures: Reelin methylation changes, higher global efficiency and improving global cognitive performance were found. Present findings provide a neurobiological insight into potential CR-led epigenetics-neurocircuitry modifications driving cognitive plasticity.
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPsychiatry
dc.subjectCognitive remediation
dc.subjectNeuroplasticity
dc.subjectFunctional connectivity
dc.subjectBrain efficiency
dc.subjectDNA methylation
dc.subjectNEUROTROPHIC FACTOR
dc.subjectPERIPHERAL-BLOOD
dc.subjectNEUROPSYCHOLOGICAL PERFORMANCE
dc.subjectINDIVIDUAL-DIFFERENCES
dc.subjectEPIGENETIC REGULATION
dc.subjectREELIN EXPRESSION
dc.subjectPREFRONTAL CORTEX
dc.subjectSYNAPTIC FUNCTION
dc.subjectMOUSE MODEL
dc.subjectPROMOTER
dc.typeArticle
dc.date.updated2023-03-23T06:54:35Z
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.jpsychires.2020.03.013
dc.description.sourcetitleJOURNAL OF PSYCHIATRIC RESEARCH
dc.description.volume126
dc.description.page122-133
dc.published.statePublished
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