Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.numecd.2022.07.019
DC Field | Value | |
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dc.title | Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy | |
dc.contributor.author | Lai JS | |
dc.contributor.author | Yuan WL | |
dc.contributor.author | Ong CN | |
dc.contributor.author | Tan KH | |
dc.contributor.author | Yap F | |
dc.contributor.author | Chong YS | |
dc.contributor.author | Gluckman PD | |
dc.contributor.author | Godfrey KM | |
dc.contributor.author | Lee YS | |
dc.contributor.author | Chan JKY | |
dc.contributor.author | Chan SY | |
dc.contributor.author | Chong MFF | |
dc.date.accessioned | 2023-03-21T08:43:46Z | |
dc.date.available | 2023-03-21T08:43:46Z | |
dc.date.issued | 2022-08-05 | |
dc.identifier.citation | Lai JS, Yuan WL, Ong CN, Tan KH, Yap F, Chong YS, Gluckman PD, Godfrey KM, Lee YS, Chan JKY, Chan SY, Chong MFF (2022-08-05). Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy. Nutrition, Metabolism & Cardiovascular Diseases 32 (12) : 2811-2821. ScholarBank@NUS Repository. https://doi.org/10.1016/j.numecd.2022.07.019 | |
dc.identifier.issn | 0939-4753 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/238270 | |
dc.description.abstract | Background and aims: Few studies examined the influence of carotenoids and vitamin E on blood pressure or hypertension during and after pregnancy. We related perinatal plasma concentrations of carotenoids and vitamin E (in individual forms and in combination) to blood pressure and hypertension at late pregnancy and 4 years post-pregnancy. Methods and results: In 684 women of the Growing Up in Singapore Towards Healthy Outcomes cohort, we quantified plasma carotenoids and vitamin E concentrations at delivery. Systolic blood pressure and diastolic blood pressure (SBP and DBP) around 37-39 weeks' gestation were extracted from obstetric records and measured at 4 years post-pregnancy. Principal component analysis derived patterns of carotenoids (CP) and vitamin E. Associations were examined using linear or logistic regressions adjusting for confounders. Two carotenoids (CP1: ?-carotene, ?-carotene, and lutein; CP2: zeaxanthin, lycopene, and ?-cryptoxanthin) and one vitamin E (?-, ?-, and ?-tocopherols) patterns were derived. CP1 (1SD score increment) was associated with lower SBP and DBP [? (95% CI): -2.36 (-3.47, -1.26) and -1.37 (-2.21, -0.53) mmHg] at late pregnancy> and 4 years post-pregnancy [-1.45 (-2.72, -0.18) and -0.99 (-1.98, -0.01) mmHg]. Higher ?-cryptoxanthin concentrations were associated with lower SBP and DBP [-1.50 (-2.49, -0.51) and -1.20 (-1.95, -0.46) mmHg] at late pregnancy. Individual vitamin E and their pattern were not associated with blood pressure or hypertension. Conclusion: Higher perinatal ?-carotene, ?-carotene, and lutein concentrations are associated with lower blood pressure in women at late pregnancy and post-pregnancy. Foods rich in these carotenoids, such as red-, orange-, and dark-green-colored vegetables, might be beneficial for blood pressure during and after pregnancy. | |
dc.publisher | Elsevier Inc. | |
dc.subject | Blood pressure | |
dc.subject | Carotenoids | |
dc.subject | Post-pregnancy | |
dc.subject | Pregnancy | |
dc.subject | Vitamin E | |
dc.type | Article | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | DEAN'S OFFICE (MEDICINE) | |
dc.contributor.department | DEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH) | |
dc.contributor.department | PAEDIATRICS | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1016/j.numecd.2022.07.019 | |
dc.description.sourcetitle | Nutrition, Metabolism & Cardiovascular Diseases | |
dc.description.volume | 32 | |
dc.description.issue | 12 | |
dc.description.page | 2811-2821 | |
dc.published.state | Unpublished | |
Appears in Collections: | Elements Staff Publications |
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