Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s11357-022-00537-z
DC Field | Value | |
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dc.title | Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain | |
dc.contributor.author | Ng, Gavin Yong-Quan | |
dc.contributor.author | Sheng, Dominic Paul Lee Kok | |
dc.contributor.author | Bae, Han-Gyu | |
dc.contributor.author | Kang, Sung Wook | |
dc.contributor.author | Fann, David Yang-Wei | |
dc.contributor.author | Park, Jinsu | |
dc.contributor.author | Kim, Joonki | |
dc.contributor.author | Alli-Shaik, Asfa | |
dc.contributor.author | Lee, Jeongmi | |
dc.contributor.author | Kim, Eunae | |
dc.contributor.author | Park, Sunyoung | |
dc.contributor.author | Han, Jeung-Whan | |
dc.contributor.author | Karamyan, Vardan | |
dc.contributor.author | Okun, Eitan | |
dc.contributor.author | Dheen, Thameem | |
dc.contributor.author | Hande, Manoor Prakash | |
dc.contributor.author | Vemuganti, Raghu | |
dc.contributor.author | Mallilankaraman, Karthik | |
dc.contributor.author | Lim, Lina HK | |
dc.contributor.author | Kennedy, Brian K | |
dc.contributor.author | Drummond, Grant R | |
dc.contributor.author | Sobey, Christopher G | |
dc.contributor.author | Gunaratne, Jayantha | |
dc.contributor.author | Mattson, Mark P | |
dc.contributor.author | Foo, Roger Sik-Yin | |
dc.contributor.author | Jo, Dong-Gyu | |
dc.contributor.author | Arumugam, Thiruma V | |
dc.date.accessioned | 2023-03-01T08:53:52Z | |
dc.date.available | 2023-03-01T08:53:52Z | |
dc.date.issued | 2022-03-31 | |
dc.identifier.citation | Ng, Gavin Yong-Quan, Sheng, Dominic Paul Lee Kok, Bae, Han-Gyu, Kang, Sung Wook, Fann, David Yang-Wei, Park, Jinsu, Kim, Joonki, Alli-Shaik, Asfa, Lee, Jeongmi, Kim, Eunae, Park, Sunyoung, Han, Jeung-Whan, Karamyan, Vardan, Okun, Eitan, Dheen, Thameem, Hande, Manoor Prakash, Vemuganti, Raghu, Mallilankaraman, Karthik, Lim, Lina HK, Kennedy, Brian K, Drummond, Grant R, Sobey, Christopher G, Gunaratne, Jayantha, Mattson, Mark P, Foo, Roger Sik-Yin, Jo, Dong-Gyu, Arumugam, Thiruma V (2022-03-31). Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain. GEROSCIENCE 44 (4) : 2171-2194. ScholarBank@NUS Repository. https://doi.org/10.1007/s11357-022-00537-z | |
dc.identifier.issn | 2509-2715 | |
dc.identifier.issn | 2509-2723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/237757 | |
dc.description.abstract | Intermittent fasting (IF) remains the most effective intervention to achieve robust anti-aging effects and attenuation of age-related diseases in various species. Epigenetic modifications mediate the biological effects of several environmental factors on gene expression; however, no information is available on the effects of IF on the epigenome. Here, we first found that IF for 3 months caused modulation of H3K9 trimethylation (H3K9me3) in the cerebellum, which in turn orchestrated a plethora of transcriptomic changes involved in robust metabolic switching processes commonly observed during IF. Second, a portion of both the epigenomic and transcriptomic modulations induced by IF was remarkably preserved for at least 3 months post-IF refeeding, indicating that memory of IF-induced epigenetic changes was maintained. Notably, though, we found that termination of IF resulted in a loss of H3K9me3 regulation of the transcriptome. Collectively, our study characterizes the novel effects of IF on the epigenetic-transcriptomic axis, which controls myriad metabolic processes. The comprehensive analyses undertaken in this study reveal a molecular framework for understanding how IF impacts the metabolo-epigenetic axis of the brain and will serve as a valuable resource for future research. | |
dc.language.iso | en | |
dc.publisher | SPRINGER | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Geriatrics & Gerontology | |
dc.subject | Cerebellum | |
dc.subject | Epigenetics | |
dc.subject | Intermittent fasting | |
dc.subject | Metabolism | |
dc.subject | Transcriptomics | |
dc.subject | WEB SERVER | |
dc.subject | EXPRESSION | |
dc.subject | METHYLATION | |
dc.subject | HOMEOSTASIS | |
dc.subject | GENERATION | |
dc.subject | OXIDATION | |
dc.subject | H3K9ME3 | |
dc.subject | MUSCLE | |
dc.subject | MEMORY | |
dc.type | Article | |
dc.date.updated | 2023-03-01T05:35:05Z | |
dc.contributor.department | ANATOMY | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | MECHANOBIOLOGY INSTITUTE | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.1007/s11357-022-00537-z | |
dc.description.sourcetitle | GEROSCIENCE | |
dc.description.volume | 44 | |
dc.description.issue | 4 | |
dc.description.page | 2171-2194 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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11357_2022_Article_537.pdf | 10.44 MB | Adobe PDF | CLOSED | None |
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