Please use this identifier to cite or link to this item:
https://doi.org/10.1002/iub.2552
DC Field | Value | |
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dc.title | Mast cells: Therapeutic targets for COVID-19 and beyond | |
dc.contributor.author | Lam, Hiu Yan | |
dc.contributor.author | Tergaonkar, Vinay | |
dc.contributor.author | Kumar, Alan Prem | |
dc.contributor.author | Ahn, Kwang Seok | |
dc.date.accessioned | 2023-02-14T03:16:54Z | |
dc.date.available | 2023-02-14T03:16:54Z | |
dc.date.issued | 2021-09-21 | |
dc.identifier.citation | Lam, Hiu Yan, Tergaonkar, Vinay, Kumar, Alan Prem, Ahn, Kwang Seok (2021-09-21). Mast cells: Therapeutic targets for COVID-19 and beyond. IUBMB LIFE 73 (11) : 1278-1292. ScholarBank@NUS Repository. https://doi.org/10.1002/iub.2552 | |
dc.identifier.issn | 1521-6543 | |
dc.identifier.issn | 1521-6551 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/237217 | |
dc.description.abstract | Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of preformed mediators residing within their secretory granules and newly synthesize a broad spectrum of inflammatory and immunomodulatory mediators. These unique features of MCs enable them to act as sentinels in response to rapid changes within their microenvironment. There is increasing evidence now that MCs play prominent roles in other pathophysiological processes besides allergic inflammation. In this review, we highlight the recent findings on the emerging roles of MCs in the pathogenesis of coronavirus disease-2019 (COVID-19) and discuss the potential of MCs as novel therapeutic targets for COVID-19 and other non-allergic inflammatory diseases. | |
dc.language.iso | en | |
dc.publisher | WILEY | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Cell Biology | |
dc.subject | coronavirus | |
dc.subject | COVID-19 | |
dc.subject | host defense | |
dc.subject | inflammation | |
dc.subject | innate immunity | |
dc.subject | mast cells | |
dc.subject | HUMANIZED MOUSE MODEL | |
dc.subject | CUTANEOUS MASTOCYTOSIS | |
dc.subject | ACTIVATION | |
dc.subject | CHYMASE | |
dc.subject | METHYLPREDNISOLONE | |
dc.subject | INFLAMMATION | |
dc.subject | PROGENITORS | |
dc.subject | POPULATION | |
dc.subject | INFECTION | |
dc.subject | SURVIVAL | |
dc.type | Review | |
dc.date.updated | 2023-02-13T06:33:23Z | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | PHARMACOLOGY | |
dc.contributor.department | PATHOLOGY | |
dc.description.doi | 10.1002/iub.2552 | |
dc.description.sourcetitle | IUBMB LIFE | |
dc.description.volume | 73 | |
dc.description.issue | 11 | |
dc.description.page | 1278-1292 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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File | Description | Size | Format | Access Settings | Version | |
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Mast cells Therapeutic targets for COVID-19 and beyond.pdf | 2.37 MB | Adobe PDF | CLOSED | None |
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