DEHYDROAROMATIZATION OF CYCLIC ALKENES DIRECTED BY (NHC)PD CATALYST & SOFTWARE DEVELOPMENT FOR LABORATORY AUTOMATION

Abstract

The development of efficient syntheses of valuable structures such as aromatic compounds and laboratory automation are two prevalent topics in chemical society. On the one side, by redirecting the traditional redox catalytic cycles through a dual-function (NHC)Pd-H catalyst, we have successfully achieved the dehydrogenative aromatization reactions of both endo- and exo-cyclic olefins through transfer-dehydrogenation and chain-walking isomerization. Through the fine-tuning of olefin regulators, the desired reactivity and chemo-selectivity could be obtained. On the other side, with the design of interface programming, we have constructed customized software for laboratory automation without the requirement of computational expertise. Chemists would be able to program their own automation procedures to incorporate various laboratory instruments, and the software has been successfully applied in several automation programs. Overall, we believe these studies could contribute to the theoretical and practical development of the chemical society.