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https://doi.org/10.1186/s40200-015-0148-z
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dc.title | Contribution of the TCF7L2 rs7903146 (C/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon | |
dc.contributor.author | Guewo-Fokeng, M | |
dc.contributor.author | Sobngwi, E | |
dc.contributor.author | Atogho-Tiedeu, B | |
dc.contributor.author | Donfack, OS | |
dc.contributor.author | Noubiap, JJN | |
dc.contributor.author | Ngwa, EN | |
dc.contributor.author | Mato-Mofo, EP | |
dc.contributor.author | Fosso, PP | |
dc.contributor.author | Djahmeni, E | |
dc.contributor.author | Djokam-Dadjeu, R | |
dc.contributor.author | Evehe, MS | |
dc.contributor.author | Aminkeng, F | |
dc.contributor.author | Mbacham, WF | |
dc.contributor.author | Mbanya, JC | |
dc.date.accessioned | 2022-12-01T09:22:33Z | |
dc.date.available | 2022-12-01T09:22:33Z | |
dc.date.issued | 2015-04-14 | |
dc.identifier.citation | Guewo-Fokeng, M, Sobngwi, E, Atogho-Tiedeu, B, Donfack, OS, Noubiap, JJN, Ngwa, EN, Mato-Mofo, EP, Fosso, PP, Djahmeni, E, Djokam-Dadjeu, R, Evehe, MS, Aminkeng, F, Mbacham, WF, Mbanya, JC (2015-04-14). Contribution of the TCF7L2 rs7903146 (C/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon. Journal of Diabetes and Metabolic Disorders 14 (1) : 26-. ScholarBank@NUS Repository. https://doi.org/10.1186/s40200-015-0148-z | |
dc.identifier.issn | 2251-6581 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/235120 | |
dc.description.abstract | Background: Data on the genetic variants for type 2 diabetes mellitus (T2DM) in sub-Saharan African populations are very scarce. This study aimed to investigate the association of transcription factor 7-like (TCF7L2) with T2DM in a Cameroonian population and explore possible genotype-phenotype correlation.Methods: This is a case-control study involving 37 T2DM patients and 37 non-diabetic volunteers of Cameroonian ethnicity aged 40 years old and above. We collected clinical and biological data to determine phenotypic traits. TCF7L2 was analyzed by genotyping for rs7903146 (C/T) using PCR-RFLP. Biochemical analyses were performed using a spectrophotometer with Chronolab kits. Statistical analyses were carried out using IBM SPSS, PS and Quanto.Results: TCF7L2 was associated with T2DM in this Cameroonian population (p = 0.013 for alleles, and p = 0.013 for genotypes). The risk allele was C (9.5% patients vs. 0% healthy controls, OR = 16.56) and the protective allele was T (90.5% patients vs. 100.0% healthy controls, OR = 0.06). The risk genotype was C/T (18.9% patients vs. 0% healthy controls, OR = 18.44), while the protective genotype was T/T (81.1% patients vs. 100.0% healthy controls, OR = 0.054). The statistical power was 99.99%. TCF7L2 was not preferentially associated with a specific disease phenotype.Conclusion: TCF7L2 is associated with T2DM in this Cameroonian population. The association is not dependent on a specific T2DM phenotype. Clinical genetic testing for TCF7L2 can help to predict the occurrence of T2DM in Cameroon. | |
dc.publisher | Springer Science and Business Media LLC | |
dc.source | Elements | |
dc.subject | Cameroon | |
dc.subject | Genetic association | |
dc.subject | Sub-Saharan Africa | |
dc.subject | Transcription factor 7-like 2 (TCF7L2) | |
dc.subject | Type 2 diabetes | |
dc.type | Article | |
dc.date.updated | 2022-11-30T18:51:49Z | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1186/s40200-015-0148-z | |
dc.description.sourcetitle | Journal of Diabetes and Metabolic Disorders | |
dc.description.volume | 14 | |
dc.description.issue | 1 | |
dc.description.page | 26- | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Contribution of the TCF7L2 rs7903146 (CT) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon.pdf | 395.33 kB | Adobe PDF | OPEN | Published | View/Download |
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