Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41419-021-03766-w
DC Field | Value | |
---|---|---|
dc.title | The GAR/RGG motif defines a family of nuclear alarmins | |
dc.contributor.author | Wu, Shan | |
dc.contributor.author | Teo, Boon Heng Dennis | |
dc.contributor.author | Wee, Seng Yin Kelly | |
dc.contributor.author | Chen, Junjie | |
dc.contributor.author | Lu, Jinhua | |
dc.date.accessioned | 2022-10-26T09:12:19Z | |
dc.date.available | 2022-10-26T09:12:19Z | |
dc.date.issued | 2021-05-01 | |
dc.identifier.citation | Wu, Shan, Teo, Boon Heng Dennis, Wee, Seng Yin Kelly, Chen, Junjie, Lu, Jinhua (2021-05-01). The GAR/RGG motif defines a family of nuclear alarmins. Cell Death and Disease 12 (5) : 477. ScholarBank@NUS Repository. https://doi.org/10.1038/s41419-021-03766-w | |
dc.identifier.issn | 2041-4889 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/233721 | |
dc.description.abstract | The nucleus is the target of autoantibodies in many diseases, which suggests intrinsic nuclear adjuvants that confer its high autoimmunogenicity. Nucleolin (NCL) is one abundant nucleolar autoantigen in systemic lupus erythematosus (SLE) patients and, in lupus-prone mice, it elicits autoantibodies early. With purified NCL, we observed that it was a potent alarmin that activated monocytes, macrophages and dendritic cells and it was a ligand for TLR2 and TLR4. NCL released by necrotic cells also exhibited alarmin activity. The NCL alarmin activity resides in its glycine/arginine-rich (GAR/RGG) motif and can be displayed by synthetic GAR/RGG peptides. Two more GAR/RGG-containing nucleolar proteins, fibrillarin (FBRL) and GAR1, were also confirmed to be novel alarmins. Therefore, the GAR/RGG alarmin motif predicts a family of nucleolar alarmins. The apparent prevalence of nucleolar alarmins suggests their positive contribution to tissue homeostasis by inducing self-limiting tissue inflammation with autoimmunity only occurring when surveillance is broken down. © 2021, The Author(s). | |
dc.publisher | Springer Nature | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.description.doi | 10.1038/s41419-021-03766-w | |
dc.description.sourcetitle | Cell Death and Disease | |
dc.description.volume | 12 | |
dc.description.issue | 5 | |
dc.description.page | 477 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1038_s41419-021-03766-w.pdf | 2.28 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License