Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0009110
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dc.titlePrevalence of simian malaria parasites in macaques of Singapore
dc.contributor.authorLi, Meizhi Irene
dc.contributor.authorMailepessov, Diyar
dc.contributor.authorVythilingam, Indra
dc.contributor.authorLee, Vernon
dc.contributor.authorLam, Patrick
dc.contributor.authorNg, Lee Ching
dc.contributor.authorTan, Cheong Huat
dc.date.accessioned2022-10-13T07:57:32Z
dc.date.available2022-10-13T07:57:32Z
dc.date.issued2021-01-25
dc.identifier.citationLi, Meizhi Irene, Mailepessov, Diyar, Vythilingam, Indra, Lee, Vernon, Lam, Patrick, Ng, Lee Ching, Tan, Cheong Huat (2021-01-25). Prevalence of simian malaria parasites in macaques of Singapore. PLoS Neglected Tropical Diseases 15 (1) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0009110
dc.identifier.issn1935-2727
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/233268
dc.description.abstractPlasmodium knowlesi is a simian malaria parasite currently recognized as the fifth causative agent of human malaria. Recently, naturally acquired P. cynomolgi infection in humans was also detected in Southeast Asia. The main reservoir of both parasites is the long-tailed and pig-tailed macaques, which are indigenous in this region. Due to increased urbanization and changes in land use, there has been greater proximity and interaction between the long-tailed macaques and the general population in Singapore. As such, this study aims to deter-mine the prevalence of simian malaria parasites in local macaques to assess the risk of zoo-nosis to the general human population. Screening for the presence of malaria parasites was conducted on blood samples from 660 peridomestic macaques collected between Jan 2008 and Mar 2017, and 379 wild macaques collected between Mar 2009 and Mar 2017, using a Pan-Plasmodium-genus specific PCR. Positive samples were then screened using a simian Plasmodium species-specific nested PCR assay to identify the species of parasites (P. knowlesi, P. coatneyi, P. fieldi, P. cynomolgi, and P. inui) present. All the peridomestic macaques sampled were tested negative for malaria, while 80.5% of the 379 wild macaques were infected. All five simian Plasmodium species were detected; P. cynomolgi being the most prevalent (71.5%), followed by P. knowlesi (47.5%), P. inui (42.0%), P. fieldi (32.5%), and P. coatneyi (28.5%). Co-infection with multiple species of Plasmodium parasites was also observed. The study revealed that Singapore’s wild long-tailed macaques are natural hosts of the five simian malaria parasite species, while no malaria was detected in all perido-mestic macaques tested. Therefore, the risk of simian malaria transmission to the general human population is concluded to be low. However, this can be better demonstrated with the incrimination of the vectors of simian malaria parasites in Singapore. © 2021 Li et al.
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1371/journal.pntd.0009110
dc.description.sourcetitlePLoS Neglected Tropical Diseases
dc.description.volume15
dc.description.issue1
dc.description.page1-12
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