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dc.titleOcular Delivery of Predatory Bacteria with Cryomicroneedles Against Eye Infection
dc.contributor.authorCui, Mingyue
dc.contributor.authorZheng, Mengjia
dc.contributor.authorWiraja, Christian
dc.contributor.authorChew, Sharon Wan Ting
dc.contributor.authorMishra, Arti
dc.contributor.authorMayandi, Venkatesh
dc.contributor.authorLakshminarayanan, Rajamani
dc.contributor.authorXu, Chenjie
dc.identifier.citationCui, Mingyue, Zheng, Mengjia, Wiraja, Christian, Chew, Sharon Wan Ting, Mishra, Arti, Mayandi, Venkatesh, Lakshminarayanan, Rajamani, Xu, Chenjie (2021-09-08). Ocular Delivery of Predatory Bacteria with Cryomicroneedles Against Eye Infection. Advanced Science 8 (21) : 2102327. ScholarBank@NUS Repository.
dc.description.abstractThe development of potent antibiotic alternatives with rapid bactericidal properties is of great importance in addressing the current antibiotic crisis. One representative example is the topical delivery of predatory bacteria to treat ocular bacterial infections. However, there is a lack of suitable methods for the delivery of predatory bacteria into ocular tissue. This work introduces cryomicroneedles (cryoMN) for the ocular delivery of predatory Bdellovibrio bacteriovorus (B. bacteriovorus) bacteria. The cryoMN patches are prepared by freezing B. bacteriovorus containing a cryoprotectant medium in a microneedle template. The viability of B. bacteriovorus in cryoMNs remains above 80% as found in long-term storage studies, and they successfully impede the growth of gram-negative bacteria in vitro or in a rodent eye infection model. The infection is significantly relieved by nearly six times through 2.5 days of treatment without substantial effects on the cornea thickness and morphology. This approach represents the safe and efficient delivery of new class of antimicrobial armamentarium to otherwise impermeable ocular surface and opens up new avenues for the treatment of ocular surface disorders. © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH
dc.publisherJohn Wiley and Sons Inc
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.subjectdrug delivery
dc.subjecteye infection
dc.subjectocular disease
dc.subjectpredatory bacteria
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.sourcetitleAdvanced Science
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