Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-020-20308-8
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dc.title | Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy | |
dc.contributor.author | Lechner, Matt | |
dc.contributor.author | Schartinger, Volker H. | |
dc.contributor.author | Steele, Christopher D. | |
dc.contributor.author | Nei, Wen Long | |
dc.contributor.author | Ooft, Marc Lucas | |
dc.contributor.author | Schreiber, Liesa-Marie | |
dc.contributor.author | Pipinikas, Christodoulos P. | |
dc.contributor.author | Chung, Grace Tin-Yun | |
dc.contributor.author | Chan, Yuk Yu | |
dc.contributor.author | Wu, Feng | |
dc.contributor.author | To, Ka-Fai | |
dc.contributor.author | Tsang, Chi Man | |
dc.contributor.author | Pearce, Wayne | |
dc.contributor.author | Morelli, Daniele | |
dc.contributor.author | Philpott, Martin | |
dc.contributor.author | Masterson, Liam | |
dc.contributor.author | Nibhani, Reshma | |
dc.contributor.author | Wells, Graham | |
dc.contributor.author | Bell, Christopher G. | |
dc.contributor.author | Koller, Julia | |
dc.contributor.author | Delecluse, Susanne | |
dc.contributor.author | Yip, Yim Ling | |
dc.contributor.author | Liu, Jacklyn | |
dc.contributor.author | Forde, Cillian T. | |
dc.contributor.author | Forster, Martin D. | |
dc.contributor.author | Jay, Amrita | |
dc.contributor.author | Dudás, József | |
dc.contributor.author | Krapp, Annika | |
dc.contributor.author | Wan, Simon | |
dc.contributor.author | Uprimny, Christian | |
dc.contributor.author | Sprung, Susanne | |
dc.contributor.author | Haybaeck, Johannes | |
dc.contributor.author | Fenton, Tim R. | |
dc.contributor.author | Chester, Kerry | |
dc.contributor.author | Thirlwell, Christina | |
dc.contributor.author | Royle, Gary | |
dc.contributor.author | Marafioti, Teresa | |
dc.contributor.author | Gupta, Rajeev | |
dc.contributor.author | Indrasari, Sagung Rai | |
dc.contributor.author | Herdini, Camelia | |
dc.contributor.author | Slim, Mohd Afiq Mohd | |
dc.contributor.author | Indrawati, I. | |
dc.contributor.author | Sutton, Liam | |
dc.contributor.author | Fles, Renske | |
dc.contributor.author | Tan, Bing | |
dc.contributor.author | Yeong, Joe | |
dc.contributor.author | Jain, Amit | |
dc.contributor.author | Han, Shuting | |
dc.contributor.author | Wang, Haitao | |
dc.contributor.author | Loke, Kelvin S. H. | |
dc.contributor.author | He, Wan | |
dc.contributor.author | Xu, Ruilian | |
dc.contributor.author | Jin, Hongtao | |
dc.contributor.author | Cheng, Zhiqiang | |
dc.contributor.author | Howard, David | |
dc.contributor.author | Hwang, Peter H. | |
dc.contributor.author | Le, Quynh-Thu | |
dc.contributor.author | Tay, Joshua K. | |
dc.contributor.author | West, Robert B. | |
dc.contributor.author | Tsao, Sai Wah | |
dc.contributor.author | Meyer, Tim | |
dc.contributor.author | Riechelmann, Herbert | |
dc.contributor.author | Oppermann, Udo | |
dc.contributor.author | Delecluse, Henri-Jacques | |
dc.contributor.author | Willems, Stefan M. | |
dc.contributor.author | Chua, Melvin L. K. | |
dc.contributor.author | Busson, Pierre | |
dc.contributor.author | Lo, Kwok Wai | |
dc.contributor.author | Wollmann, Guido | |
dc.contributor.author | Pillay, Nischalan | |
dc.contributor.author | Vanhaesebroeck, Bart | |
dc.contributor.author | Lund, Valerie J. | |
dc.date.accessioned | 2022-10-13T06:48:36Z | |
dc.date.available | 2022-10-13T06:48:36Z | |
dc.date.issued | 2021-01-05 | |
dc.identifier.citation | Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, Lund, Valerie J. (2021-01-05). Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. Nature Communications 12 (1) : 117. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-20308-8 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/233091 | |
dc.description.abstract | Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. We show that SSTR2 expression is induced by the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-?B pathway. Using cell-based and preclinical rodent models, we demonstrate the therapeutic potential of SSTR2 targeting using a cytotoxic drug conjugate, PEN-221, which is found to be superior to FDA-approved SSTR2-binding cytostatic agents. Furthermore, we reveal significant correlation of SSTR expression with increased rates of survival and report in vivo uptake of the SSTR2-binding 68Ga-DOTA-peptide radioconjugate in PET-CT scanning in a clinical trial of NPC patients (NCT03670342). These findings reveal a key role in EBV-associated NPC for SSTR2 in infection, imaging, targeted therapy and survival. © 2021, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.type | Article | |
dc.contributor.department | OTOLARYNGOLOGY | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.description.doi | 10.1038/s41467-020-20308-8 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 12 | |
dc.description.issue | 1 | |
dc.description.page | 117 | |
Appears in Collections: | Elements Staff Publications |
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